Evidence map›Paper›PMID 42404165›Full record

ArticleJournal of bone oncology2026

Single-cell fixed RNA profiling of the osteosarcoma clinical Spectrum identifies ADAMTS12 and RNASE1 as key drivers of the metastatic niche.

Nguyen Van Khanh, Tran Trung Dung, Hoang Hai, Nguyen Tran Quang Sang, Tran Duc Thanh, Dang Minh Quang, Nguyen Thi Ha, Nguyen Bui Tam Chi, Pham Tuan Anh, Pham Minh Duc and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bone oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Nguyen Van KhanhDepartment of Global Education and Medical Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Tran Trung DungDepartment of Orthopaedic Surgery, College of Health Science, Vin University, Hanoi, Viet Nam.
Hoang HaiDepartment of Global Education and Medical Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Nguyen Tran Quang SangDepartment of Global Education and Medical Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Tran Duc ThanhDepartment of Orthopaedic Surgery, College of Health Science, Vin University, Hanoi, Viet Nam.
Dang Minh QuangDepartment of Orthopaedic Surgery, College of Health Science, Vin University, Hanoi, Viet Nam.
Nguyen Thi HaDepartment of Global Education and Medical Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Nguyen Bui Tam ChiDepartment of Global Education and Medical Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Pham Tuan AnhDepartment of Global Education and Medical Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Pham Minh DucDepartment of Global Education and Medical Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Tran Van BaoDepartment of Global Education and Medical Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Tran Dang Anh HuyenDepartment of Global Education and Medical Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Vu Thi PhuongDepartment of Pathology, Vinmec Times City International Hospital, Vinmec Healthcare System, Hanoi, Viet Nam.
Ha Thi Thu HienDepartment of Pathology, Vinmec Times City International Hospital, Vinmec Healthcare System, Hanoi, Viet Nam.
Le Thi PhuongDepartment of Pathology, Vinmec Times City International Hospital, Vinmec Healthcare System, Hanoi, Viet Nam.
Nguyen Thi Hong NhungVinmec-Vinuni Institute of Immunology, VinUniversity, Viet Nam.
Norifumi KawadaEndowsed Departments of Liver Cancer Treatment and Homeostatic Regulation, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Le Thi Thanh ThuyDepartment of Global Education and Medical Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteosarcoma (OS) suffers from stagnant survival rates due to high metastatic potential and genomic complexity. Here, we present a high-resolution single-cell transcriptomic atlas of the OS ecosystem using single-cell fixed RNA profiling (FLEX) of 40,401 cells across four clinical stages: treatment-naïve, post-chemotherapy, recurrent, and lung metastatic. We identified a metastasis-enriched malignant subpopulation, OB_3, characterized by aggressive transcriptional signatures and governed by

Indexed as

ADAMTS12MetastasisOsteosarcomaRNASE1Transcriptomics

Identifiers

PMID42404165
PMCPMC13330631

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.