Evidence map›Paper›PMID 42404120›Full record

Trial reportFrontiers in neurology

Intermittent theta burst stimulation enhances the efficacy of brain-computer interface in upper limb rehabilitation post-stroke.

Xiaoqian Xia, Xiaoyu Kang, Lingyun Jia, Qianhui Wang, Linyao Zhang, Ruoqing Zhang, Yizheng Wang, Xiaoli Wu, Xiaogang Chen, Lixu Liu

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaoqian XiaSchool of Rehabilitation Medicine, Capital Medical University, Beijing, China.
Xiaoyu KangDepartment of Physical Therapy, Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing, China.
Lingyun JiaSchool of Rehabilitation Medicine, Capital Medical University, Beijing, China.
Qianhui WangSchool of Rehabilitation Medicine, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Linyao ZhangSchool of Rehabilitation Medicine, Capital Medical University, Beijing, China.
Ruoqing ZhangInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Yizheng WangSchool of Rehabilitation Medicine, Capital Medical University, Beijing, China.
Xiaoli WuSchool of Rehabilitation Medicine, Capital Medical University, Beijing, China.
Xiaogang ChenInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Lixu LiuSchool of Rehabilitation Medicine, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: "BCI illiteracy," characterized by insufficient Methods: This exploratory single-center randomized controlled trial (RCT) enrolled 18 subacute stroke patients, randomized to: BCI group (conventional rehab + BCI training) or iTBS + BCI group (conventional rehab + iTBS applied to the affected M1 cortex followed sequentially by BCI training). Interventions occurred 10 times over 2 weeks. Primary outcome: Fugl-Meyer Assessment - Upper Extremity (FMA-UE) score. Secondary outcomes: Modified Barthel Index (MBI), BCI task accuracy (BCI-TA). Mechanistic measures: sensorimotor cortex ERD and Laterality Index (LI). Results: In this exploratory study, FMA-UE improvement was greater in the iTBS + BCI group, with significant differences at week 4 ( Conclusion: This exploratory study suggests that sequential iTBS combined with BCI may have potential benefits in enhancing upper limb function in stroke patients. It boosts affected cortical excitability, improves BCI decoding efficiency, and remodels motor network activation, offering a new strategy to overcome "BCI illiteracy." Clinical trial registration: https://www.chictr.org.cn/showproj.html?proj=173657, Identifier: ChiCTR2300069203.

Indexed as

brain–computer interfaceevent-related desynchronizationintermittent theta burst stimulationneuroplasticitystroke rehabilitationupper limb function

Identifiers

PMID42404120
PMCPMC13328359

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.