ArticleFrontiers in dental medicine2026
Salivary biomarker profiling in prediabetes-associated periodontitis: role of adiponectin, resistin, and total matrix metalloproteinase-8.
Article in Frontiers in dental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aim: This study evaluated the diagnostic potential of salivary total matrix metalloproteinase-8 (tMMP-8), adiponectin, and resistin in prediabetic adults with and without periodontitis and examined their associations with systemic and periodontal parameters. Materials and methods: Systemically healthy and prediabetic adults, categorized by periodontal status, underwent clinical, anthropometric, and metabolic assessments. A total of 84 adults aged 25-55 years were enrolled and stratified into four groups: prediabetes with periodontitis (PreDM-PD, Results: Participants with periodontitis had significantly higher periodontal parameters ( Conclusion: Salivary tMMP-8 and adiponectin composite profiles outperform single markers, supporting their use in non-invasive periodontal risk screening in metabolically vulnerable adults. Elevated tMMP-8 links periodontal and metabolic inflammation in prediabetes.
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