ArticleFrontiers in cardiovascular medicine2026
Gut frailty in chronic heart failure: clinical determinants and distinct microbial signatures.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Gut frailty is a critical yet under-recognized sub-phenotype in chronic heart failure (CHF) that may exacerbate systemic inflammation. This study aimed to identify risk factors for gut frailty in CHF and characterize associated gut microbiome alterations. Methods: In this cross-sectional study of 270 CHF patients, gut frailty was defined as a Gastrointestinal Symptom Rating Scale score of ≥3. Clinical determinants were identified via multivariable logistic regression. 16S rRNA sequencing was performed on a balanced sub-cohort ( Results: A meat-rich diet independently increased gut frailty risk (OR = 3.995; 95% CI: 1.107-16.110; Conclusion: Gut frailty in CHF constitutes a distinct syndrome modulated by diet and characterized by profound dysbiosis and metabolic reprogramming. Targeting the gut-heart axis through nutritional or microbiome-directed interventions may offer a novel strategy to mitigate frailty in heart failure.
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