ArticleFrontiers in cardiovascular medicine2026
Associations of the TyG index, remnant cholesterol levels, and the severity of coronary artery disease: findings from a retrospective study.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study aimed to investigate whether the triglyceride-glucose (TyG) index mediates the association between remnant cholesterol (RC) and coronary artery disease (CAD) severity and to evaluate their combined association with multi-vessel CAD. Methods: In this retrospective study, anonymized data from CAD patients undergoing coronary computed tomography angiography (CCTA) or coronary angiography (CAG) between 2019 and 2022 were analyzed Results: A total of 592 patients (64.7% male; mean age, 62 years) were included in the analysis. The TyG index was positively correlated with RC ( Conclusions: The TyG index is positively correlated with RC and is significantly associated with CAD severity. Furthermore, the TyG index partially mediates the association between RC and CAD severity. Combined assessment of the TyG index and RC may improve metabolic risk stratification in patients with CAD.
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