ArticleJournal of asthma and allergy2026
Pandemic-Associated Sensitization Patterns and Burden in Chinese Children with Allergic Rhinitis: A Retrospective Phase-Stratified Study.
Article in Journal of asthma and allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The coronavirus disease 2019 (COVID-19) pandemic and associated non-pharmaceutical interventions may have altered children's indoor, outdoor, and dietary exposures. However, phase-specific data on allergen sensitization patterns in pediatric allergic rhinitis (AR) remain limited. Objective: To assess phase-specific changes in serum allergen-specific immunoglobulin E (sIgE) sensitization patterns, intensity, co-sensitization, and burden in children with AR in Eastern China. Methods: We analyzed 12,702 children aged 0-18 years with clinically diagnosed AR who underwent sIgE testing for 19 inhalant and food allergens in Eastern China from 2018 to 2024. Sensitization was compared across pre-pandemic (2018-2019), lockdown (2020-2022), and post-lockdown (2023-2024) phases using Pearson's Results: Compared with the pre-pandemic phase, the lockdown and post-lockdown phases showed divergent sensitization trajectories, with higher sensitization to several inhalant allergens and lower sensitization to selected food allergens, although selected seafood allergens increased in later phases. Post-lockdown, adjusted analyses showed higher odds for selected indoor, outdoor, and seafood allergens, while other allergens remained stable or showed non-monotonic patterns. Strong-positive responses, selected co-sensitization patterns, and ≥4 sensitizations were also more common post-lockdown. Conclusion: Across the pre-pandemic, lockdown, and post-lockdown periods, children with AR showed divergent trajectories of inhalant and food allergen sensitization, as well as greater post-lockdown sensitization intensity and complexity. These findings reflect phase-specific associations rather than direct causal effects of the pandemic. They may help inform post-pandemic risk stratification in pediatric AR, with greater attention to inhalant allergen control and more cautious interpretation of food sIgE positivity in clinical context.
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