ReviewCureus2026
Impact of Exercise-Based Pulmonary Rehabilitation on Systemic Inflammation in Chronic Obstructive Pulmonary Disease (COPD): A Narrative Review on Evidence and Insights.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionChronic obstructive pulmonary disease (COPD) is characterized by persistent airway inflammation, progressive airflow limitation, and frequent exacerbations that adversely affect functional capacity and clinical outcomes. Pulmonary rehabilitation (PR) is an established non-pharmacological intervention that improves exercise tolerance, symptom burden, and quality of life. However, its effects on systemic inflammation remain unclear.
methodsThis narrative review aimed to synthesize current evidence on the impact of exercise-based PR on systemic inflammatory markers in COPD. The review further outlines pulmonary rehabilitation and explores the mechanisms and clinical significance of systemic inflammation in COPD, including its impact on exacerbations, prognosis, and comorbidities, as well as PR's influence on inflammatory pathways. A comprehensive literature search was conducted using PubMed, Scopus, and EMBASE databases. Studies published in English over the past 15 years involving human participants were considered. Included studies were randomized controlled trials and clinical studies evaluating the effect of PR or exercise-based interventions on systemic inflammatory biomarkers.
resultsPR programs were predominantly multicomponent, combining aerobic and resistance training with breathing exercises and education, typically delivered over 8-12 weeks. Evidence regarding their impact on systemic inflammation was inconsistent despite improvements in physiological and functional outcomes, along with exercise capacity, symptom control, and quality of life. Pulmonary rehabilitation may modulate systemic inflammation in COPD, but effects are variable and not consistently demonstrated. Its clinical benefits are more reliably reflected in functional and symptomatic improvements rather than biomarker changes. Further standardized, high-quality studies are needed to clarify the long-term anti-inflammatory potential of PR.
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