Evidence map›Paper›PMID 42403814›Full record

ReviewCureus2026

Interplay Between Periodontal Health and Renal Function in Terms of Severity of Chronic Kidney Disease: A Comprehensive Review.

Krish Relan, Ankrishik Sardar, Katherine Rodriguez, Daniel Leyva, Mary Girgis, Jinal Choudhari, Sultan Ahmed, Echols Marti, Komal Relan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Krish RelanMedicine, University of Miami, Coral Gables, USA.
Ankrishik SardarBiology, Nova Southeastern University, Davie, USA.
Katherine RodriguezMedicine, Ponce Health Sciences University, Ponce, PRI.
Daniel LeyvaBiology, Florida International University, Miami, USA.
Mary GirgisMedicine, University of Florida, Gainesville, USA.
Jinal ChoudhariMedicine, Larkin Community Hospital, South Miami, USA.
Sultan AhmedMedicine, Larkin Community Hospital, South Miami, USA.
Echols MartiResearch and Academic Affairs, Larkin Community Hospital, Miami, USA.
Komal RelanDentistry, Bahri Dental Group, Jacksonville, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic kidney disease (CKD) and periodontal disease (PD) represent significant global health burdens with an increasingly recognized, yet mechanistically complex, interrelationship. This review examines current literature from 2015 to 2025 on the association between dental health and renal function, with select foundational studies from 2008 to 2014 retained for mechanistic context and explicitly disclosed as such. We explored shared biological mechanisms, including systemic inflammation, oxidative stress, impaired neutrophil function, and altered vitamin D metabolism, and identified a critical research gap regarding the definitive direction of causality. By synthesizing clinical data on biomarkers and management challenges, this review provides a direction for future longitudinal research aimed at clarifying the periodontal disease-CKD axis and supports the adoption of integrated dental-nephrological care models.

Indexed as

ckddental hygieneesrdgingivitisgum diseaseperiodontal diseaseperiodontitisrenal function

Identifiers

PMID42403814
PMCPMC13331033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.