ArticleCureus2026
Clinico-Serological Profile of Total IgE Levels Detected by Enzyme-Linked Fluorescent Assay (ELFA) Among Pediatric Patients With Allergic Conditions.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND AND
objectiveThe global rate of existence for pediatric allergies is increasing; the importance of IgE as the predominant immune component involved in allergic disease (or type 1 hypersensitivity) is acknowledged throughout the world. Total serum IgE levels are widely used to evaluate patients with atopic diseases, but references correlating IgE levels determined by enzyme-linked fluorescent assay (ELFA) with clinical symptoms are limited in the pediatric population. This study aimed to analyze both the clinical and serological characteristics of total IgE levels in patients with suspected allergy. MATERIALS AND
methodsA cross-sectional study of 237 pediatric patients (aged zero to 18 years old) was performed at a tertiary care center in Bengaluru, Karnataka, India, with an automated ELFA (VIDAS; bioMérieux, Marcy-l'Étoile, FRA) to measure total serum IgE. Demographic data and clinical characteristics were recorded. The chi-square test analyzed the association between age, sex, and elevated IgE levels. Lastly, Spearman's rank correlation examined the relationship between eosinophils and IgE.
resultsThere was a statistically significant association between elevated serum IgE levels (>100 kIU/L) and age, with the highest prevalence found among the 11 to 15 years age group (p=0.0049). The common IgE-associated diagnoses were asthma (20.1%), n=32, and allergic rhinitis (AR) (18.2%), n=29. The majority of patients had IgE levels between 100 and 1000 kIU/L. There was a statistically significant, positive correlation between IgE levels and absolute eosinophil count (AEC) (rho=0.249; p=0.008). Males displayed a greater frequency of elevated IgE levels, but this relationship was not statistically significant.
conclusionTotal serum IgE estimation by ELFA is a reliable adjunctive tool for diagnosis and monitoring of pediatric allergic diseases, particularly respiratory conditions, atopic conditions, immunological disorders, and correlation of elevated IgE levels with eosinophilic inflammation.
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