Antenatal Corticosteroid Exposure in Late Preterm Infants: Clinical Considerations in Diabetic Mothers.

Hannah Daniel, Esther S Kim, Tristan Grogan, Juanita Lewis, Kalpashri Kesavan, Supriya Bavisetty

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Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Hannah DanielDepartment of Pediatrics, University of California, Los Angeles Mattel Children's Hospital, Los Angeles, USA.

Esther S KimDepartment of Neonatology, Olive View-University of California, Los Angeles Medical Center, Sylmar, USA.

Tristan GroganDepartment of Medicine Statistics Core, University of California, Los Angeles David Geffen School of Medicine, Los Angeles, USA.

Juanita LewisDepartment of Neonatology, Olive View-University of California, Los Angeles Medical Center, Sylmar, USA.

Kalpashri KesavanDepartment of Neonatology, University of California, Los Angeles David Geffen School of Medicine, Los Angeles, USA.

Supriya BavisettyDepartment of Pediatrics, Olive View-University of California, Los Angeles Medical Center, Sylmar, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective The objective of this study was to evaluate the association between antenatal corticosteroid (ACS) administration and respiratory and metabolic outcomes among late preterm infants, with a secondary exploratory analysis of infants of diabetic mothers. Methods We performed a retrospective cohort study of 85 neonates born between 33 0/7 and 35 6/7 weeks' gestation at a county hospital to investigate neonatal outcomes according to ACS exposure. Outcomes included respiratory support requirement, duration to room air, hypoglycemia, and hospital length of stay. Results Among 85 infants, 18 (21%) received no ACS, 24 (28%) received one dose, and 43 (51%) received two doses. ACS exposure was not associated with increased hypoglycemia (p = 0.163) or hospital length of stay (p = 0.647). Among infants requiring respiratory support (n = 30), greater ACS exposure was associated with fewer days to room air (Spearman's rho = -0.37, p = 0.044). Conclusions In this small retrospective cohort, ACS exposure was associated with shorter time to room air among late preterm infants requiring respiratory support, without increased risk of hypoglycemia. These findings are exploratory and hypothesis generating, particularly for infants of diabetic mothers.

Indexed as

antenatal corticosteroidsbetamethasonelate preterm infantsmaternal diabetesneonatal hypoglycemianeonatal respiratory supportpreterm birthrespiratory outcomes

Identifiers

PMID42403807

DOI10.7759/cureus.110222

PMCPMC13332481

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