ArticleCureus2026
Distribution of Virulence Determinants (esp, cylA, and gelE) Among Clinical Enterococcus Isolates: A Molecular Study From Central India.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
backgroundThe genus Enterococcus contains gram-positive cocci. Before the widespread use of antibiotics, enterococci were known causes of endocarditis, urinary tract infections (UTIs), and intra-abdominal infections. The three most important enterococcal virulence agents discovered are cytolysin (cylA), enterococcal surface protein (esp), and gelatinase (gelE). Serious concerns about infectious illnesses are raised by the increasing number of genes for antibiotic resistance. MATERIALS AND
methodsThe study was granted permission by the Institutional Ethical Committee (MU/Research/EC/Ph.D./2021/58), and every single sample was taken from patients who were hospitalized at the Index Medical College Hospital and Research Center in Indore, India. One hundred and six enterococcal isolates were collected between December 2021 and August 2024, and their species distribution was examined. Standard molecular techniques were used to identify virulence genes, such as cytolysin (cylA), enterococcal surface protein (esp), and gelatinase (gelE).
resultsAmong 106 Enterococcus isolates analyzed by reverse transcription polymerase chain reaction (RT-PCR), the esp gene was the most prevalent (74.53%), followed by cylA (55.66%) and gelE (45.28%).
conclusionThe study reveals a significant pathogenic potential of Enterococcus strains, evidenced by the high prevalence of major virulence genes (esp, cylA, and gelE).
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