Evidence map›Paper›PMID 42403700›Full record

ArticleBrain, behavior, & immunity - health2026

Does sex moderate health and Alzheimer's disease risk tied to early educational experiences? The reducing inequities through social and educational change follow-up in early adulthood extension study protocol.

Saché M Coury, Savannah D Lopez, Paul W Savoca, Elizabeth M Gaines, Brandon Parenti, Alondra Razon, Kulwant K Dosanjh, Jennifer S Labus, Jonathan P Jacobs, Teal S Eich and 3 more

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Article in Brain, behavior, & immunity - health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Saché M CouryDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Savannah D LopezDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Paul W SavocaDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Elizabeth M GainesDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Brandon ParentiDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Alondra RazonDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Kulwant K DosanjhDavid Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Jennifer S LabusDavid Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Jonathan P JacobsGoodman-Luskin Microbiome Center, University of California, Los Angeles, Los Angeles, CA, USA.
Teal S EichLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Mitchell D WongDavid Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Bridget L CallaghanDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Jennifer A SilversDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) -a progressive neurodegenerative disorder that is characterized by insidious cognitive decline and distinct neuropathological features- significantly impacts daily life functioning and behavior and is disproportionally prevalent in women compared to men. The reasons and risk factors for sex-based disparities in AD prevalence are still largely unclear, however early life exposures (e.g., education and stress) may be important contributing factors. Therefore, it is increasingly important to disentangle the complex interactions between known early environmental protective and risk factors and genetic susceptibility and uncover how these factors might impact and shape neurobiological processes. Moreover, it is critical to assess how these processes, in turn, influence later cognitive and brain health outcomes that may confer sex-specific pathways of risk for developing AD. In this paper we describe the rationale and study protocol for The Reducing Inequities through Social and Educational Change Follow-Up in Early Adulthood Extension (RISE-Up EA+; R01AG089426) study, a follow-up study of 300 participants aged 24-26 years old that leverages a natural quasi-experimental cohort to investigate how health outcomes tied to socioeconomic mobility opportunity may contribute to sex-specific vulnerability for developing AD later in life. To examine how sex-specific vulnerabilities related to early educational experiences may set the stage for later AD risk, we will assess self-report, cognitive, biological (e.g., inflammation and microbiome), and brain health measures. Results from this work provide the opportunity to better understand how adolescent mobility opportunities might contribute to later life health outcomes and influence sex-specific developmental pathways important for later AD risk.

Identifiers

PMID42403700
PMCPMC13330673

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.