ArticleBiochemistry and biophysics reports2026
Intranasal administration of Aloe-derived nanovesicles attenuates early radiation-induced lung injury.
Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Background: Radiation-induced lung injury (RILI) is a common complication of thoracic radiotherapy and typically progresses from acute radiation pneumonitis to late-stage pulmonary fibrosis. This study investigated whether intranasally delivered Methods: A single-fraction 20 Gy whole-thorax irradiation model was established in C57BL/6 N mice. Mice in the treatment group received intranasal AVNVs at 5 mg kg Results: In vivo, intranasal AVNV administration attenuated early histopathological lung injury, reduced bronchoalveolar lavage fluid protein levels by 42%, and improved oxidative stress- and tissue injury-related indicators, including SOD, GSH, and LDH. AVNVs were efficiently internalized by both MLE-12 cells and RAW264.7 macrophages. In vitro, AVNV pretreatment reduced γ-H2AX expression, alleviated radiation-induced oxidative stress, and decreased IL-6 and TNF-α production. Conclusion: Intranasally delivered AVNVs exert early protective effects against radiation-induced lung injury, at least in part by modulating oxidative stress and inflammatory responses. These findings suggest that AVNVs may represent a promising noninvasive candidate for early intervention in RILI. Further studies are warranted to determine whether these early benefits translate into sustained protection against radiation pneumonitis and pulmonary fibrosis.
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