Evidence map›Paper›PMID 42403594›Full record

ReviewJournal of multidisciplinary healthcare2026

A Critical Review of PET/CT Assessment After CAR-T Cell Therapy in Large B-Cell Lymphoma, Limitations of Current Criteria, Emerging Biomarkers, and a Framework for Standardised Evaluation.

Layal K Jambi, Saeed M Kabrah

Abstract readReview
In one paragraph

Review in Journal of multidisciplinary healthcare, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Layal K Jambi *Radiological Sciences Department, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.ORCID 0000-0002-2098-6925
Saeed M Kabrah *Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.ORCID 0000-0003-2992-8497

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chimeric antigen receptor (CAR) T-cell therapy has fundamentally altered the management of relapsed or refractory Large B-Cell Lymphoma (LBCL). Despite remarkable clinical efficacy, the radiologic evaluation of therapeutic response remains highly problematic. Standard assessment frameworks, notably the Lugano classification and the Deauville Five-Point Scale (D5PS), were calibrated for cytotoxic chemoimmunotherapy and demonstrate profound inadequacies when applied to the unique biological kinetics of cellular immunotherapy. This review critically examines the limitations of standard

Indexed as

chimeric antigen receptor T-cell therapycirculating tumour DNActDNAdeauville scorelarge B-cell lymphomametabolic tumour volumeMTVPET/CTpositron emission tomography computed tomographyprognostic biomarkersradiomics

Identifiers

PMID42403594
PMCPMC13330758

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.