ArticleRegenerative therapy2026
Comparison of intra-articular injectable polydactyly-derived chondrocyte sheet-minis with direct transplantation of intact polydactyly-derived chondrocyte sheets in a rat full-thickness cartilage defect model.
Article in Regenerative therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Polydactyly-derived chondrocyte (PD) sheets are being developed as an allogeneic cell sheet therapy for cartilage defects associated with knee osteoarthritis. Although intact PD sheets can promote hyaline cartilage repair, transplantation requires invasive open procedures. Injectable fragments of PD sheets (PD sheet-minis) may reduce invasiveness. However, their Methods: PD cells were isolated from discarded cartilage tissue obtained during polydactyly surgery. PD sheets and PD sheet-minis were fabricated for 14 days using temperature-responsive culture inserts and RepCell plates, respectively. PD cells, PD sheets, and PD sheet-minis were compared by cell counting, viability assays, flow cytometry, soluble factor assays, and quantitative polymerase chain reaction. A full-thickness cartilage defect was created in the femoral trochlea of male athymic nude rats. The animals were randomized by body weight into vehicle, PD cell suspension, PD sheet-mini suspension, or intact PD sheet transplantation groups (n = 6 each). Hindlimb weight-bearing was assessed after surgery, and cartilage repair was evaluated histologically 4 weeks after transplantation. Results: The viable cell numbers administered per knee were comparable between PD cells, PD sheet-minis, and intact PD sheets. The PD sheet-minis and PD sheets showed similar surface marker profiles, whereas PD cells showed significantly lower CD26 and higher CD146, CD49a, and CD166 expression. Compared to PD cells, PD sheet-minis secreted more melanoma inhibitory activity and dickkopf-related protein 1 and less transforming growth factor-β, monocyte chemoattractant protein-1, and matrix metalloproteinase-3. Gene expression analysis revealed lower Conclusions: PD sheet-minis retained several sheet-like
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