Evidence map›Paper›PMID 42403470›Full record

ArticleAmerican journal of preventive cardiology2026

Differences of plaque burden measures on CCTA in younger men and women.

Anum Asif, C Noel Bairey Merz, Heidi Gransar, Donghee Han, Martha Gulati, Alan Rozanski, John D Friedman, Sean W Hayes, Louise E J Thomson, Damini Dey and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of preventive cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Rethinking risk: The prognostic power of coronary plaque in young women.American journal of preventive cardiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anum AsifBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
C Noel Bairey MerzBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Heidi GransarDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Donghee HanDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Martha GulatiBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Alan RozanskiDepartment of Cardiology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
John D FriedmanDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Sean W HayesDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Louise E J ThomsonDepartment of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Damini DeyDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Balaji TamarappooDepartment of Cardiology, Mayo Clinic, Scottsdale, AZ, USA.
Daniel BermanDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Funding

The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE)U54AG065141 · NIA · CEDARS-SINAI MEDICAL CENTER · PI BAIREY MERZ, CATHLEEN NOEL · 2020 to 2024
$8.7M
The Microvascular Aging Effects - Women's Evaluation of Systemic aging Tenacity in Heart, Brain and Frailty (MAE-WEST HBF) ("You are never too old to become younger!")U54AG094168 · NIA · CEDARS-SINAI MEDICAL CENTER · PI chi-hong tseng · 2025 to 2026
$4.5M
Women's Ischemia Syndrome Evaluation (WISE) - Mechanisms of Coronary Microvascular Dysfunction Leading to Pre-Heart Failure with Preserved Ejection Fraction (HFpEF)R01HL146158 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI BAIREY MERZ, CATHLEEN NOEL · 2019 to 2023
$3.7M
Whole-Heart Myocardial Blood Flow Quantification Using MRIR01HL124649 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI LI, DEBIAO · 2015 to 2018
$3.3M
Myocardial Steatosis in Women with Coronary Microvascular Dysfunction: Defining the Pathway to Heart Failure with Preserved Ejection Fraction (HFpEF)R01HL153500 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI WEI, JANET · 2021 to 2025
$3.2M
NHLBI NIH HHS R01 HL124649NHLBI NIH HHS R01 HL146158NHLBI NIH HHS R01 HL153500NIA NIH HHS U54 AG065141NIA NIH HHS U54 AG094168
6 · The paper itself

Abstract

Importance: The extent and severity of coronary artery disease (CAD) on coronary CT angiography (CCTA) is predictive of mortality, cardiovascular death, and non-fatal myocardial infarction in both men and women; however, associations of various measures of coronary plaque burden with prognosis in younger women and men has had little study. Objective: To compare prognostic significance of CAD plaque burden and distribution on CCTA in women and men <60. Design: 3813 consecutive patients (age: 49.4 ± 8.1 years, 36 % women) without CAD history who underwent CCTA (2007-2019) with clinical follow-up. Setting: Single academic medical center. Interventions: None. Main Outcomes: CCTA plaque burden was assessed by stenosis severity, segment involvement score (SIS), segment stenosis score (SSS), and coronary artery calcium (CAC) scores. Primary endpoint: all-cause mortality (ACM); secondary outcome: ACM or non-fatal MI (NFMI). Results: 180 (4.7 %) ACM occurred over a median of 7.4 years, Severity of stenosis, SIS, SSS and extent of CAC were higher in men compared to women (all Conclusions: Prognostic significance of multiple measures of plaque burden identified by CCTA had greater prognostic impact in younger women, compared with younger men. Trial Registration: NA.

Indexed as

Coronary CTACoronary CT angiographyPlaque burdenPrognosisSex-differences

Identifiers

PMID42403470
PMCPMC13329505

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.