ArticleFrontiers in pediatrics2026
Serum ferritin critical threshold fluctuations predict antipsychotic treatment discontinuation in pediatric Tic disorders: a retrospective cohort study.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To determine whether dynamic fluctuations in serum ferritin below a critical threshold (30 ng/mL) independently predict antipsychotic treatment discontinuation in children with tic disorders, and to evaluate effect modification by antipsychotic class. Methods: A single-center retrospective cohort study analyzed electronic medical records (2022-2024) of 228 children (aged 6-16 years) with Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)-diagnosed tic disorders receiving first-line antipsychotics. Participants were stratified by ferritin fluctuation patterns: high-fluctuation (coefficient of variation [CV] ≥25% with ≥1 value <30 ng/mL; Results: Over a 22.4-month median follow-up, high-fluctuation patients showed significantly higher discontinuation rates (60.3% vs. 24.0%; Conclusion: Dynamic ferritin fluctuations below 30 ng/mL independently predict antipsychotic discontinuation and poorer symptomatic improvement in pediatric tic disorders, with heightened risk for typical antipsychotic users. Serial ferritin monitoring may identify high-risk patients for early intervention.
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