Evidence map›Paper›PMID 42403345›Full record

ArticleTransactions of the Royal Society of Tropical Medicine and Hygiene2026

Predisposition to Ascaris lumbricoides reinfection in the Geshiyaro project in southern Ethiopia.

Olivia Simmonds, Rosie Maddren, Benjamin Collyer, Birhan Abtew, Ewnetu Firdawek Liyew, Melkie Chernet, Getachew Tollera, Geremew Tasew, Esayas Knife, Mahlet Belachew and 3 more

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Article in Transactions of the Royal Society of Tropical Medicine and Hygiene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Olivia SimmondsDepartment of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, Imperial College London, 90 Wood Lane, London W12 0BZ, United Kingdom.ORCID 0009-0002-3508-3320
Rosie MaddrenDepartment of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, Imperial College London, 90 Wood Lane, London W12 0BZ, United Kingdom.ORCID 0000-0001-9363-3103
Benjamin CollyerDepartment of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, Imperial College London, 90 Wood Lane, London W12 0BZ, United Kingdom.
Birhan AbtewDepartment of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, Imperial College London, 90 Wood Lane, London W12 0BZ, United Kingdom.
Ewnetu Firdawek LiyewBacterial, Parasitic and Zoonotic Disease Research Directorate, Ethiopian Public Health Institute, Swaziland Street, 2PWJ P8C, Addis Ababa, Ethiopia.
Melkie ChernetBacterial, Parasitic and Zoonotic Disease Research Directorate, Ethiopian Public Health Institute, Swaziland Street, 2PWJ P8C, Addis Ababa, Ethiopia.
Getachew TolleraBacterial, Parasitic and Zoonotic Disease Research Directorate, Ethiopian Public Health Institute, Swaziland Street, 2PWJ P8C, Addis Ababa, Ethiopia.
Geremew TasewBacterial, Parasitic and Zoonotic Disease Research Directorate, Ethiopian Public Health Institute, Swaziland Street, 2PWJ P8C, Addis Ababa, Ethiopia.
Esayas KnifeBacterial, Parasitic and Zoonotic Disease Research Directorate, Ethiopian Public Health Institute, Swaziland Street, 2PWJ P8C, Addis Ababa, Ethiopia.
Mahlet BelachewBacterial, Parasitic and Zoonotic Disease Research Directorate, Ethiopian Public Health Institute, Swaziland Street, 2PWJ P8C, Addis Ababa, Ethiopia.
Mesay HailuBacterial, Parasitic and Zoonotic Disease Research Directorate, Ethiopian Public Health Institute, Swaziland Street, 2PWJ P8C, Addis Ababa, Ethiopia.
Yasin AwolBacterial, Parasitic and Zoonotic Disease Research Directorate, Ethiopian Public Health Institute, Swaziland Street, 2PWJ P8C, Addis Ababa, Ethiopia.
Roy M AndersonDepartment of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, Imperial College London, 90 Wood Lane, London W12 0BZ, United Kingdom.

Funding

Children's Investment Fund Foundation R-1805-02741
6 · The paper itself

Abstract

objectivesPredisposition to reinfection is characterized by certain individuals repeatedly acquiring infection at higher rates than others in the population despite treatment. As endemic regions approach low prevalence levels, such individuals will act as reservoirs of infection and contribute to sustaining transmission cycles in communities. This study investigated evidence for individual-level predisposition to Ascaris lumbricoides infections using longitudinal data from the Geshiyaro project in southern Ethiopia.

methodsLongitudinal parasitological data collected over 7 years were analysed. Kendall's tau (τ) correlation coefficient was used to assess temporal persistence of infection between successive survey rounds, and Kendall's coefficient of concordance (W) was used to evaluate long-term stability in individuals' relative infection risk over many years of survey rounds.

resultsPositive correlations in infection status between survey rounds were observed (τ = 0.10-0.30, P < .001). Moderate concordance in infection ranking across the study period was also detected (W = 0.43, 95% CI: 0.42-0.45; P < .001), indicating persistent individual-level predisposition over many years of treatment and reinfection.

conclusionThese findings demonstrate sustained heterogeneity in infection risk within endemic communities. As transmission declines, identifying individuals predisposed to reinfection may help inform targeted or complementary 'test-and-treat' strategies to support interruption of A. lumbricoides transmission.

Indexed as

AscariasisAscaris lumbricoidesReinfectionAdolescentAdultAnimalsChildDisease SusceptibilityEthiopiaFemaleHumansLongitudinal StudiesMalePrevalenceRisk FactorsYoung AdultAscaris lumbricoidesEthiopialongitudinal studiesmass drug administrationreinfectionsoil-transmitted helminths

Identifiers

PMID42403345
PMCPMC13635670

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.