Evidence map›Paper›PMID 42403170›Full record

ArticleDevelopment (Cambridge, England)2026

Expanding the Caenorhabditis elegans toolkit with gonad explants.

Réda M Zellag, Eric Cheng, Abigail R Gerhold, Jean-Claude Labbé

Abstract read
PubMed Publisher
In one paragraph

Article in Development (Cambridge, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Réda M ZellagDepartment of Biology, McGill University, 1205 avenue Docteur Penfield, Montréal, QC, H2A 1B1, Canada.ORCID 0000-0002-4137-1751
Eric ChengDepartment of Biology, McGill University, 1205 avenue Docteur Penfield, Montréal, QC, H2A 1B1, Canada.ORCID 0009-0000-7003-6648
Abigail R GerholdDepartment of Biology, McGill University, 1205 avenue Docteur Penfield, Montréal, QC, H2A 1B1, Canada.ORCID 0000-0003-0108-9986
Jean-Claude LabbéInstitute for Research in Immunology and Cancer (IRIC), Université de Montréal, C.P. 6128, Succ. Centre-ville, Montréal, QC, H3C 3J7, Canada.ORCID 0000-0003-0520-4566

Funding

CIHR PJT-525829McGill University
6 · The paper itself

Abstract

Animal development is a complex process that requires the coordination of a plethora of pathways in space and time. In several species, the availability of tissue explants has provided a simplified context that facilitates mechanistic investigations, particularly into dynamic events. Here, we demonstrate that extruded Caenorhabditis elegans gonads are a viable tissue explant system for this model organism. Using live-cell imaging, we show that C. elegans gonad explants retain many tissue properties that have been documented in vivo, including mitosis, meiosis, apoptosis and gametogenesis. We further show that C. elegans explants are acutely responsive to treatment with the microtubule depolymerizing drug nocodazole. Thus, C. elegans gonad explants are a tractable system in which live-cell imaging and acute drug treatment can be combined to decipher the mechanisms governing germline development.

Indexed as

Caenorhabditis elegansGonadsAnimalsApoptosisMeiosisMitosisNocodazoleNocodazoleCaenorhabditis elegansDrug treatmentEx vivo cultureGonad developmentTissue explant

Identifiers

PMID42403170

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.