Evidence map›Paper›PMID 42403014›Full record

ArticleAllergy2026

Dendritic Cell α-Ketoglutarate Regulates Tfh Polarization in Allergy.

Anuj Tharakan, Xufeng Qu, Carmen Camarena, Araba Abaidoo-Myles, Parth Naik, Jeremy Allegood, Ankit Kumar, Mihir Pokhriyal, Joseph C Lownik, Matthew P Zellner and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Anuj TharakanDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA.
Xufeng QuDepartment of Biostatistics, Virginia Commonwealth University, Richmond, Virginia, USA.
Carmen CamarenaCenter for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia, USA.
Araba Abaidoo-MylesDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA.
Parth NaikDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA.
Jeremy AllegoodDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia, USA.
Ankit KumarDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA.
Mihir PokhriyalDepartment of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.ORCID https://orcid.org/0009-0001-5918-900X
Joseph C LownikCenter for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia, USA.
Matthew P ZellnerDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA.
Grayson W WayDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA.
Jinze LiuDepartment of Biostatistics, Virginia Commonwealth University, Richmond, Virginia, USA.
Lauren Ashley CowartDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia, USA.
Stephanie C EisenbarthNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-1244-208X
Joseph W LandryDepartment of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.
Daniel H ConradDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA.
Rebecca K MartinDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA.ORCID https://orcid.org/0000-0001-9948-5463

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Kim Felder Rhoads · 1985 to 2026
$51.0M
Research Supplement to Promote Diversity in Health Related ResearchUL1TR002649 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2018 to 2022
$19.1M
Metabolic perturbations in conventional dendritic cells modulate Tfh13 induction in asthmatic sensitizationR01HL162991 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Rebecca Kelley Martin · 2023 to 2026
$2.3M
IL-25 as a master regulator of extrafollicular benign IgER56AI139658 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI MARTIN, REBECCA KELLEY · 2019 to 2019
$380k
Division of Intramural Research, National Institute of Allergy and Infectious Diseases R56AI139658Medical College of Virginia Foundation's George and Lavina Blick Scholar FundNCATS NIH HHS UL1 TR002649NCATS NIH HHS UL1TR002649NCI NIH HHS P30 CA016059NHLBI Division of Intramural Research R01HL162991NHLBI NIH HHS R01 HL162991NIAID NIH HHS R56 AI139658Virginia Commonwealth University's Commercialization Fund
6 · The paper itself

Abstract

Initiation of allergic responses requires activation of specialized subsets of T follicular helper (Tfh) cells called Tfh13 cells. Differentiation of these cells from naïve CD4

Identifiers

PMID42403014
PMCPMC13520972

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.