Evidence map›Paper›PMID 42403007›Full record

ArticleInternational journal of urology : official journal of the Japanese Urological Association2026

Long-Term Oncologic Outcomes After Laparoscopic Radical Nephroureterectomy: A Contemporary Analysis From a Japanese Multicenter Cohort.

Toru Kanno, Ryoichi Saito, Yuki Kita, Takeshi Sano, Shigeki Koterazawa, Toshifumi Takahashi, Yuto Hattori, Go Kobori, Tomohiro Fukui, Toshiya Akao and 6 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of urology : official journal of the Japanese Urological Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Toru KannoDepartment of Urology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.ORCID https://orcid.org/0000-0001-9445-4035
Ryoichi SaitoDepartment of Urology, Hyogo Medical University, Hyogo, Japan.ORCID https://orcid.org/0000-0002-3163-8723
Yuki KitaDepartment of Urology, Kyoto University School of Medicine, Kyoto, Japan.
Takeshi SanoDepartment of Urology, Kansai Medical University, Osaka, Japan.
Shigeki KoterazawaDepartment of Urology, Ijinkai Takeda General Hospital, Kyoto, Japan.
Toshifumi TakahashiDepartment of Urology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan.
Yuto HattoriDepartment of Urology, Kobe City Medical Center General Hospital, Kobe, Japan.ORCID https://orcid.org/0000-0002-1488-9811
Go KoboriDepartment of Urology, Hamamatsu Rosai Hospital, Hamamatsu, Japan.
Tomohiro FukuiDepartment of Urology, Toyooka Hospital, Toyooka, Japan.ORCID https://orcid.org/0000-0002-1904-0884
Toshiya AkaoDepartment of Urology, Rakuwakai Otowa Hospital, Kyoto, Japan.
Shotaro HatanoDepartment of Urology, Osaka Red Cross Hospital, Osaka, Japan.
Takayuki SumiyoshiDepartment of Urology, Kyoto University School of Medicine, Kyoto, Japan.
Kimihiko MasuiDepartment of Urology, Kyoto University School of Medicine, Kyoto, Japan.ORCID https://orcid.org/0000-0002-7841-1104
Takayuki GotoDepartment of Urology, Kyoto University School of Medicine, Kyoto, Japan.
Takashi KobayashiDepartment of Urology, Kyoto University School of Medicine, Kyoto, Japan.ORCID https://orcid.org/0000-0003-1069-2816
Daimonji Clinical Application Database Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate long-term oncologic outcomes and recurrence patterns after laparoscopic radical nephroureterectomy (LRNU) performed more than five years earlier. PATIENTS AND

methodsWe retrospectively analyzed patients who underwent LRNU before 2020 at nine Japanese institutions. Nonurothelial recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS) were estimated using the Kaplan-Meier method. Cox proportional hazard models were applied to identify prognostic factors. Initial recurrence sites were assessed, with particular focus on disseminated recurrence.

resultsA total of 1102 patients were included, with a median follow-up of 57 months. Clinically locally advanced disease was observed in 212 patients (19%), including 178 (16%) with cT3-4 tumors and 64 (6%) with cN-positive disease. Lymphadenectomy was performed in 557 cases (51%). The 5-year RFS rates for pT < 1, pT1, pT2, pT3, and pT4 were 92%, 87%, 70%, 48%, and 20%, respectively. The corresponding CSS rates were 96%, 94%, 81%, 61%, and 21%, and the corresponding OS rates were 84%, 78%, 71%, 53%, and 15%. Older age at surgery and advanced pathological features were independent predictors of poorer RFS, CSS, and OS. Regarding recurrence patterns, distant recurrence occurred in 203 patients (18%), local recurrence in 127 (11%), and urothelial recurrence in 489 (45%). Disseminated recurrence was rare, occurring in 25 patients (2%), including 18 with retroperitoneal carcinomatosis and 3 (0.3%) with port-site recurrence.

conclusionsOur findings suggest that LRNU provides favorable long-term oncologic outcomes with low disseminated recurrence rates, appearing comparable to historical outcomes of open surgery.

Indexed as

Carcinoma, Transitional CellKidney NeoplasmsLaparoscopyNeoplasm Recurrence, LocalNephroureterectomyUreteral NeoplasmsAgedAged, 80 and overDisease-Free SurvivalFemaleFollow-Up StudiesHumansJapanLymph Node ExcisionMaleMiddle Agedlaparoscopic radical nephroureterectomylong‐term oncologic outcomesupper tract urothelial carcinoma

Identifiers

PMID42403007
PMCPMC13334230

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.