ArticlePediatric transplantation2026
Early Response to Therapeutic Plasma Exchange as a Prognostic Indicator in Pediatric Liver Transplant Recipients with Early Allograft Dysfunction.
Article in Pediatric transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly allograft dysfunction (EAD) is a major determinant of morbidity and mortality after pediatric liver transplantation. Therapeutic plasma exchange (TPE) is increasingly used as supportive therapy, yet pediatric-specific data remain limited. We aimed to determine whether early response to TPE predicts survival in pediatric liver transplant recipients with EAD.
methodsIn this retrospective study, 15 pediatric patients (0-18 years) who developed EAD after living donor liver transplantation and received TPE (2015-2023) were analyzed. EAD was defined by Olthoff criteria. Response was assessed within 72 h using predefined criteria. Patients were classified as responders (n = 9) or non-responders (n = 6).
resultsAmong 140 pediatric liver transplant recipients, 15 (10.7%) developed EAD. The median age was 13 months (IQR: 9.1-22.6), and 80% weighed ≤ 10 kg. Responders showed significant reductions in total bilirubin (17.0 to 9.0 mg/dL; p = 0.004), INR (3.0 to 1.5; p = 0.004), AST (2239 to 150 IU/L; p = 0.004), and ALT (2467 to 200 IU/L; p = 0.004); non-responders showed no meaningful improvement. In-hospital mortality occurred exclusively among non-responders (83.3% vs. 0%; p = 0.001). Kaplan-Meier analysis revealed significant survival divergence (100% vs. 16.7% at day 45; log-rank p = 0.0005). Pre-TPE albumin was significantly lower in non-responders (2.90 vs. 3.20 g/dL; p = 0.013), highlighting albumin as a potential early bedside screening parameter for identifying patients at higher risk of non-response. One-year overall survival was 66.7%.
conclusionsEarly response to TPE within 72 h strongly discriminates survival in pediatric EAD and may serve as a practical prognostic tool. Prospective multicenter studies are warranted to validate these findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.