Evidence map›Paper›PMID 42402951›Full record

ArticleNeurogastroenterology and motility2026

Accuracy of Novice Raters for Esophageal Motility Classifications Using Functional Lumen Imaging Probe Panometry.

Cayla E Bales, Anthony J Kang, Jacob M Schauer, Keerthana Chakka, Benjamin M Moy, Chiagoziem Ogbonna, Amanda Pirola, Aidan Smires, Mark A Solinski, Rena Yadlapati and 2 more

Abstract read
In one paragraph

Article in Neurogastroenterology and motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Cayla E BalesKenneth C. Griffin Esophageal Center of Northwestern Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Anthony J KangKenneth C. Griffin Esophageal Center of Northwestern Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Jacob M SchauerDivision of Biostatistics and Informatics, Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Keerthana ChakkaKenneth C. Griffin Esophageal Center of Northwestern Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Benjamin M MoyKenneth C. Griffin Esophageal Center of Northwestern Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Chiagoziem OgbonnaKenneth C. Griffin Esophageal Center of Northwestern Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Amanda PirolaKenneth C. Griffin Esophageal Center of Northwestern Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Aidan SmiresKenneth C. Griffin Esophageal Center of Northwestern Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Mark A SolinskiKenneth C. Griffin Esophageal Center of Northwestern Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Rena YadlapatiDivision of Gastroenterology, University of California San Diego, San Diego, California, USA.
John E PandolfinoKenneth C. Griffin Esophageal Center of Northwestern Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Dustin A CarlsonKenneth C. Griffin Esophageal Center of Northwestern Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Funding

Role of altered response to volumetric distension in esophageal diseaseP01DK117824 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PATANKAR, NEELESH A. · 2018 to 2022
$7.3M
The MVP Trial: A Randomized Controlled Trial of Mechanism Guided vs PPI Strategy for Laryngopharyngeal RefluxR01DK139089 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Rena Hiren Yadlapati · 2024 to 2026
$2.0M
Evolution of the Chicago Classification: Bridging Physiology and MechanicsR01DK137775 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Dustin Allan Carlson, JOHN E PANDOLFINO · 2024 to 2026
$1.3M
Mechanism Guided Therapy for Laryngopharyngeal RefluxK23DK125266 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YADLAPATI, RENA HIREN · 2021 to 2025
$963k
NIDDK NIH HHS K23 DK125266NIDDK NIH HHS P01 DK117824NIDDK NIH HHS R01 DK137775NIDDK NIH HHS R01 DK139089
6 · The paper itself

Abstract

introductionFunctional lumen imaging probe (FLIP) Panometry classifies esophageal motility using esophagogastric junction (EGJ) opening and esophageal contractile patterns. A previous study evaluated FLIP Panometry interpretation among esophageal specialists (which demonstrated an average accuracy of 78% for FLIP motility diagnoses), but the interpretation performance of nonexperts remains unknown. This study aimed to assess the accuracy and interrater agreement of novice raters using FLIP Panometry v1.0 and the novel v2.0 (Dallas Consensus) motility classification schemes.

methodsEight non-gastroenterology trainees without previous FLIP or esophageal motility experience interpreted 40 FLIP studies. Brief training included a video tutorial and review of 10 practice studies with an esophageal specialist. Accuracy was assessed using percent agreement with the reference standard assigned by two experienced raters. Interrater agreement was assessed using intraclass correlation coefficient (ICC) and Fleiss' kappa.

resultsAccuracy of motility diagnosis was mean (95% CI) 0.73 (0.68-0.78) for v2.0 and 0.78 (0.73-0.82) for v1.0. Accuracies ≥ 78% were achieved by four raters for v2.0 and five for v1.0, while other raters' accuracies ranged from 55% to 75%. Accuracy for EGJ opening classification was 0.80 (0.75-0.84) and for contractile response pattern was 0.78 (0.74-0.83) for v2.0 and 0.78 (0.74-0.83) for v1.0. Moderate-to-good interrater agreement was observed (ICC 0.80-0.83; kappa 0.55-0.61).

conclusionFollowing brief training, some novice raters achieved accuracy akin to esophageal motility specialists when interpreting FLIP Panometry motility studies. While variation in accuracy highlights the need for improved and adequate training methods for esophageal motility interpretation, accurate FLIP Panometry interpretation was achievable among nonspecialists, supporting feasibility for broad use.

Indexed as

Clinical CompetenceEsophageal Motility DisordersEsophagogastric JunctionEsophagusHumansManometryObserver VariationReproducibility of Resultsachalasiadysphagiaendoscopyimpedancemotility

Identifiers

PMID42402951
PMCPMC13334194

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.