Evidence map›Paper›PMID 42402832›Full record

ArticleJournal of immunology research2026

Novel Biomarker for Antimitochondrial Antibodies in Systemic Sclerosis Patients.

Elvira Favoino, Silvia De Santis, Vasiliki Liakouli, Giovanna Barbuti, Sabina Piccolo, Ada Corrado, Marta Vomero, Luca Navarini, Marcella Prete, Patrizia Leone and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Elvira FavoinoLaboratory of Cellular and Molecular Immunology, Department of Interdisciplinary Medicine, University of Bari Medical School, Bari, Italy, uniba.it.ORCID https://orcid.org/0000-0002-4664-1394
Silvia De SantisLaboratory of Cellular and Molecular Immunology, Department of Interdisciplinary Medicine, University of Bari Medical School, Bari, Italy, uniba.it.ORCID https://orcid.org/0009-0006-1846-4710
Vasiliki LiakouliRheumatology Section, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy, unina2.it.ORCID https://orcid.org/0000-0002-7392-9334
Giovanna BarbutiDepartment of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy, uniba.it.ORCID https://orcid.org/0000-0002-1179-8009
Sabina PiccoloLaboratory of Cellular and Molecular Immunology, Department of Interdisciplinary Medicine, University of Bari Medical School, Bari, Italy, uniba.it.
Ada CorradoRheumatology Unit, Department of Medical and Surgery Sciences, University of Foggia, Foggia, Italy, unifg.it.ORCID https://orcid.org/0000-0001-6823-1970
Marta VomeroClinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Campus Bio-Medico, Via Álvaro del Portillo 200, Rome, 00128, Italy, unicampus.it.ORCID https://orcid.org/0000-0001-9744-5628
Luca NavariniClinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Campus Bio-Medico, Via Álvaro del Portillo 200, Rome, 00128, Italy, unicampus.it.ORCID https://orcid.org/0000-0001-8537-1510
Marcella PreteInternal Medicine Unit, Department of Interdisciplinary Medicine, University of Bari Medical School, Bari, Italy, uniba.it.ORCID https://orcid.org/0000-0001-6853-3450
Patrizia LeoneInternal Medicine Unit, Department of Interdisciplinary Medicine, University of Bari Medical School, Bari, Italy, uniba.it.ORCID https://orcid.org/0000-0002-0904-1074
Vito RacanelliCentre for Medical Sciences, Santa Chiara Hospital, Provincial Health Care Agency (APSS), University of Trento and Internal Medicine Division, Trento, Italy, apss.tn.it.ORCID https://orcid.org/0000-0002-8639-1940
Rosa Daniela GrembialeRheumatology Research Unit, Department of Health Sciences, University of Catanzaro Magna Graecia, Catanzaro, Italy, unicz.it.ORCID https://orcid.org/0000-0002-0338-6784
Piero RuscittiRheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy, univaq.it.ORCID https://orcid.org/0000-0003-3487-8551
Francesco Paolo CantatoreRheumatology Unit, Department of Medical and Surgery Sciences, University of Foggia, Foggia, Italy, unifg.it.ORCID https://orcid.org/0000-0001-9929-9177
Francesco CicciaRheumatology Section, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy, unina2.it.ORCID https://orcid.org/0000-0002-9352-1264
Roberto GiacomelliClinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Campus Bio-Medico, Via Álvaro del Portillo 200, Rome, 00128, Italy, unicampus.it.ORCID https://orcid.org/0009-0001-3409-8048
Federico PerosaRheumatic and Systemic Autoimmune Diseases Unit, Department of Interdisciplinary Medicine, University of Bari Medical School, Bari, Italy, uniba.it.ORCID https://orcid.org/0000-0002-4072-4244

Funding

CRUI-CAREEuropean Union-NextGeneration EU H53D23007500001Ministry for Universities and Research (MUR) P2022PKWF9Universita degli Studi di Bari Aldo Moro
6 · The paper itself

Abstract

objectiveWe previously identified, using a synthetic peptide, namely peptide 4.33 (p4.33), a subgroup of anti-CENP-A antibodies (Abs) recognizing an epitope shared between the CENP-A region spanning amino acids 1-17 (Ap1-17) and the E2 component of the mitochondrial pyruvate dehydrogenase complex (PDC-E2), the major mitochondrial target autoantigen in primary biliary cholangitis (PBC). Here, we evaluated whether anti-p4.33 Ab positivity may be associates with a higher prevalence of antimitochondrial Ab (AMA) in systemic sclerosis (SSc) patients.

methodsSerum samples from 145 anti-CENP

resultsOf 145 anti-CENP

conclusionsAnti-p4.33 Abs may be a useful biomarker to define a subset of SSc patients with a higher prevalence of AMA. Our findings also support the hypothesis that pathogens can trigger autoimmunity.

Indexed as

AutoantibodiesMitochondriaScleroderma, SystemicAdultAgedAutoantigensBiomarkersCentromere Protein AEpitopesFemaleHumansLiver Cirrhosis, BiliaryMaleMiddle AgedAutoantibodiesAutoantigensBiomarkersCentromere Protein AEpitopesanti-CENP-A antibodiesantimitochondrial antibodiesbiomarker riskprimary biliary cholangitissystemic sclerosis

Identifiers

PMID42402832
PMCPMC13333934

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.