Evidence map›Paper›PMID 42402781›Full record

ArticleAnnals of clinical and translational neurology2026

Factors Associated With the Rising Trend in Self-Reported Cognitive Disability Among U.S. Adults Aged 18-39 From 2013-2024.

Adam de Havenon, Ka-Ho Wong, Mirriam Mananah, Christopher D Anderson, Ada Fenick, Amy Arnsten, Arman Fesharaki-Zadeh, James C McPartland, Mary L Adams, Kevin N Sheth

Abstract read
In one paragraph

Article in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Adam de HavenonDepartment of Neurology, Yale University, New Haven, Connecticut, USA.
Ka-Ho WongDepartment of Neurology, University of Utah, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0001-9597-8105
Mirriam MananahDepartment of Neurology, Yale University, New Haven, Connecticut, USA.ORCID https://orcid.org/0009-0003-3066-4502
Christopher D AndersonDepartment of Neurology, Mass General Brigham, Boston, Massachusetts, USA.
Ada FenickDepartment of Pediatrics, Yale University, New Haven, Connecticut, USA.
Amy ArnstenDepartments of Neurology and Psychiatry, Yale University, New Haven, Connecticut, USA.
Arman Fesharaki-ZadehDepartment of Neurology, Yale University, New Haven, Connecticut, USA.
James C McPartlandChild Study Center, Yale University, New Haven, Connecticut, USA.
Mary L AdamsRetired, Connecticut Department of Public Health, Hartford, Connecticut, USA.
Kevin N ShethDepartment of Neurology, Yale University, New Haven, Connecticut, USA.ORCID https://orcid.org/0000-0003-2003-5473

Funding

Anticoagulation in ICH Survivors for Prevention and Recovery (ASPIRE)U01NS106513 · NINDS · YALE UNIVERSITY · PI Hooman Kamel, Kevin Navin Sheth · 2019 to 2026
$20.6M
Cilostazol for Prevention of Recurrent Stroke (CLARITY)UG3NS133209 · NINDS · STANFORD UNIVERSITY · PI DE HAVENON, ADAM H., LANSBERG, MAARTEN G · 2025 to 2025
$5.7M
Social networks and risk of delayed arrival to the hospital during strokeR01MD016178 · NIMHD · BRIGHAM AND WOMEN'S HOSPITAL · PI Amar Dhand, Kevin Navin Sheth · 2022 to 2026
$3.7M
The Recovery in Stroke Using PAP (RISE UP) StudyR01NR018335 · NINR · YALE UNIVERSITY · PI REDEKER, NANCY S, SHETH, KEVIN NAVIN · 2019 to 2023
$3.4M
Southern New England Partnership In Stroke Research, Innovation and Treatment (SPIRIT)U24NS107215 · NINDS · YALE UNIVERSITY · PI MARK Jay ALBERTS, Karen L Furie · 2018 to 2026
$3.0M
CAPTIVA-MRIUH3NS130228 · NINDS · YALE UNIVERSITY · PI Sepideh Amin-Hanjani, Arindam Rano Chatterjee · 2025 to 2026
$2.8M
REACH-EpiVCIDRF1NS139183 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI ANDERSON, CHRISTOPHER DAVID, ROSAND, JONATHAN · 2024 to 2024
$2.4M
Blood Pressure Variability and Ischemic Stroke Outcome (BP-VISO)R01NS130189 · NINDS · YALE UNIVERSITY · PI Adam H. de Havenon · 2023 to 2026
$2.0M
Yale Clinical Site: Investigations For Improved Neurological Treatments at Yale (INFINITY)U24NS107136 · NINDS · YALE UNIVERSITY · PI SHETH, KEVIN NAVIN, SPUDICH, SERENA S · 2018 to 2022
$1.7M
Measuring Brain Health Using Low-Field Portable MRIR21NS138995 · NINDS · YALE UNIVERSITY · PI DE HAVENON, ADAM H. · 2024 to 2024
$477k
Intensive Blood Pressure Reduction in Deep Intracerebral HemorrhageR03NS112859 · NINDS · YALE UNIVERSITY · PI FALCONE, GUIDO JOSE, SHETH, KEVIN NAVIN · 2019 to 2020
$84k
American Heart Association 17CSA33550004MGB Department of NeurologyNIH HHS U01NS069673, RF1NS139183, 21SFRN812095NIMHD NIH HHS R01 MD016178NINDS NIH HHS R01 NS130189NINDS NIH HHS R03 NS112859NINDS NIH HHS R21 NS138995NINDS NIH HHS RF1 NS139183NINDS NIH HHS U01 NS106513NINDS NIH HHS U01NS106513, R01NS11072, R01NR018335, R01EB301114, R01MD016178, R03NS112859, U24NS107215, U24NS107136NINDS NIH HHS U24 NS107136NINDS NIH HHS U24 NS107215NINDS NIH HHS UG3 NS133209NINDS NIH HHS UG3NS133209, UH3NS130228, R01NS130189, R21NS138995NINDS NIH HHS UH3 NS130228NINR NIH HHS R01 NR018335
6 · The paper itself

Abstract

objectiveBuilding on our prior Behavioral Risk Factor Surveillance System analysis identifying adults aged 18-39 as the primary driver of the national increase in self-reported cognitive disability, we examined factors associated with this rise using 2013-2024 U.S. BRFSS data.

methodsWe analyzed U.S. Behavioral Risk Factor Surveillance System data, excluding 2020 due to poor survey response, to assess trends in self-reported cognitive disability among adults aged 18-39, excluding and including respondents with depression. Cognitive disability was defined as serious difficulty concentrating, remembering, or making decisions due to a physical, mental, or emotional condition. We compared younger adults with versus without cognitive disability across sociodemographic, socioeconomic, health, and mental health characteristics. Analyses incorporated survey weighting to yield U.S. nationally representative estimates.

resultsCognitive disability prevalence increased from 5.1% in 2013 to 9.8% in 2024 (93% increase; p < 0.001). Including respondents with depression, prevalence increased from 10.0% to 17.8% (16.2 million individuals). Among younger adults with cognitive disability, employment increased (55.6% to 65.1%), lack of health insurance declined (35.7% to 19.7%), smoking decreased (28.7% to 14.1%), and physical inactivity decreased (26.9% to 22.3%). Point estimates for hypertension, hyperlipidemia, asthma, diabetes, and stroke prevalence were also lower. In contrast, frequent poor mental health (≥ 14 days/month) increased from 26.6% to 33.2%. In sensitivity analyses excluding depression and any poor mental health days, prevalence still increased from 2.8% to 5.2% (p < 0.001).

interpretationFrom 2013-2024, self-reported cognitive disability among younger United States adults nearly doubled despite improving socioeconomic and cardiometabolic indicators, highlighting a growing burden of perceived or functional cognitive difficulty.

Indexed as

cognitive disabilitycognitive impairmentyoung adults

Identifiers

PMID42402781
PMCPMC13395017

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.