ArticleRomanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
Vascular remodeling and microvessel density in inflammatory radicular cysts: a CD34 immunohistochemical analysis.
Article in Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundInflammatory radicular cysts are lesions of endodontic origin in which chronic inflammation and tissue remodeling may support cyst expansion.
aimThe present study evaluated cluster of differentiation 34 (CD34) immunoexpression as a proxy of vascular remodeling and explored a digital, artificial intelligence (AI)-assisted quantification workflow. MATERIALS AND
methodsThirty-nine inflammatory radicular cysts were processed as formalin-fixed paraffin-embedded (FFPE) specimens and immunostained with anti-CD34 antibody. Digital quantification [Deep Learning Inferred ImmunoFluorescence (DeepLIIF) and ImageJ] was performed in selected stromal areas. Lesions were stratified by cyst size (0.5-1.0 cm, 1.0-2.0 cm, >2.0 cm).
resultsTwenty-two of 39 cases were CD34-positive. In these cases, the mean proportion of CD34-positive nuclei increased with lesion size (6.67% in 0.5-1.0 cm, 15.98% in 1.0-2.0 cm, and 31.13% in >2.0 cm). Differences among size groups were significant (Kruskal-Wallis H=18.50, p=0.000096).
conclusionsLarger inflammatory radicular cysts displayed higher CD34-associated vascular signal, supporting an association between cyst size and vascular remodeling.
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