Evidence map›Paper›PMID 42402669›Full record

ArticleScientific reports2026

MT-MRI for detection of renal interstitial fibrosis in renovascular disease.

YaFei Liu, Dilbar A Abdurakhimova, Mina Al Saeedi, XiangYang Zhu, Hui Tang, Ailing Xue, Richard G Frimpong, Sanjay Misra, Gary L Schwartz, Amir Lerman and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

YaFei LiuDivision of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Dilbar A AbdurakhimovaDivision of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Mina Al SaeediDivision of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
XiangYang ZhuDivision of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Hui TangDivision of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Ailing XueDivision of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Richard G FrimpongDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Sanjay MisraDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Gary L SchwartzDivision of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Amir LermanDepartment of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, 55905, USA.
Aleksandra KuklaDivision of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Lilach O LermanDivision of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. Lerman.Lilach@Mayo.edu.ORCID http://orcid.org/0000-0002-3271-3887

Funding

Obesity-induced dysfunction of human MSC in peripheral microvascular repairR01HL158691 · NHLBI · MAYO CLINIC ROCHESTER · PI Alfonso Eirin, Lilach O Lerman · 2022 to 2026
$3.4M
Quantitative magnetization transfer MRI for evaluation of renal fibrosisR01DK122734 · NIDDK · MAYO CLINIC ROCHESTER · PI LERMAN, LILACH O · 2020 to 2023
$2.2M
Noninvasive Evaluation of Renal Allograft Fibrosis by MRIR21AG062104 · NIA · MAYO CLINIC ROCHESTER · PI LERMAN, LILACH O · 2020 to 2021
$414k
National Institute for Diabetes and Digestive and Kidney Diseases DK122734NHLBI NIH HHS HL158691NHLBI NIH HHS R01 HL158691NIA NIH HHS AG062104NIA NIH HHS R21 AG062104NIDDK NIH HHS R01 DK122734
6 · The paper itself

Abstract

We evaluated kidney fibrosis in renovascular disease (RVD) using quantitative (q) and semi-quantitative magnetization-transfer (MT) magnetic resonance imaging (MRI). Ten RVD patients and 22 healthy volunteers (HVs) were prospectively enrolled. Of HVs, 10 (HV-1) underwent imaging studies whereas plasma samples were collected from 12 others (HV-2). The qMT-derived bound-pool fraction (f) was compared to MRI-based MT imaging (MTI)-derived MT ratio (MTR), blood oxygenation-level-dependent (BOLD) R2*, and diffusion-weighted imaging (DWI) apparent diffusion coefficient (ADC). MTR was assessed at offset frequencies of 600 Hz and 1000 Hz, and RVD qMT and MTI on both 1.5T and 3.0T MRI. Additionally, we measured plasma and urinary levels of fibrogenic cytokines and micro-RNAs, and stenotic kidney (STK) perfusion and volume with multidetector computed-tomography (MDCT). At 3.0T-MRI, STK cortex and medulla qMT-f were higher in RVD vs. HV-1 (p = 0.01, p = 0.05, respectively), as was MTR-600 Hz, whereas BOLD-R2* and the DWI ADC were not different. MTR and f measured at 1.5T were comparable to those obtained at 3.0T. STK blood flow was decreased vs. the contralateral kidney (CLK) (p = 0.033) but plasma and urinary fibrogenic indices were unchanged in RVD vs. HV-2. Both f and MTI at 3.0T-MRI may be useful for noninvasive assessment of STK fibrosis, independent of magnetic-field strength. MTI is potentially more sensitive than fibrogenic cytokine levels for detecting mild RVD-related fibrosis changes.

Indexed as

BOLDFibrosisMTRqMTRenal vascular disease

Identifiers

PMID42402669
PMCPMC13634916

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.