ArticleJournal of assisted reproduction and genetics2026
Long-term maternal health outcomes following autologous in vitro fertilization compared with medically unassisted conceptions and with nulliparas.
Article in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe use of in vitro fertilization (IVF) has increased substantially, raising interest in the long-term health outcomes of women undergoing these treatments.
objectiveTo assess the association between conception through autologous IVF and the long-term incidence of chronic diseases, compared with two reference groups: women who conceived through medically unassisted conception (UC) and age-matched nulliparous women.
methodsThis retrospective cohort study used electronic health records from a large health maintenance organization and included women who delivered before age 45 between 2000 and 2018. Three pairwise comparisons were performed: IVF mothers versus UC mothers, IVF mothers versus nulliparous women, and UC mothers versus nulliparous women. For the IVF versus UC comparison, each IVF mother was matched to a UC mother by age and parity at delivery. For comparisons with nulliparous women, controls were matched by age according to the mother's age at first delivery. The delivery date served as the index date for follow-up. Primary outcomes were chronic diseases diagnosed after the index pregnancy and persisting for at least three years.
resultsThe study included 17,425 IVF mothers matched to 17,425 UC mothers, 10,358 IVF mothers matched to 10,358 nulliparous women, and 38,810 UC mothers matched to 38,810 nulliparous women. Compared with UC, IVF was associated with a higher risk of thyroid disease (HR 1.11, p < 0.05). Compared with nulliparous women, IVF mothers had higher risks of thyroid disease (HR 2.07), rheumatologic disease (HR 1.87), neurologic disease (HR 2.51), and psychiatric conditions (HR 1.34) (all p < 0.05). UC mothers also had higher risks of thyroid disease (HR 1.67), rheumatologic disease (HR 1.79), cardiology disease (HR 1.47), and psychiatric conditions (HR 1.47) compared with nulliparous women (all p < 0.05).
conclusionsLong-term health outcomes after autologous IVF were largely comparable to those after UC, except for a modestly increased risk of thyroid disease. Compared with nulliparous women, both IVF and UC mothers had higher risks of several chronic conditions, suggesting that pregnancy itself may contribute to long-term maternal health trajectories. Thyroid function monitoring may be considered for women who conceive through autologous IVF.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.