Evidence map›Paper›PMID 42402527›Full record

ArticleHeart and vessels2026

Microvascular angina beyond risk markers: the need for endotype-specific validation.

Abdülmelik Birgün, Abdullah Sarıhan, Macit Kalçık

Abstract readLetterComment
PubMed Publisher
In one paragraph

Article in Heart and vessels, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Abdülmelik BirgünDepartment of Cardiology, Hitit University Erol Olçok Education and Research Hospital, Çorum, Turkey. melikbirgun@gmail.com.ORCID http://orcid.org/0009-0008-9864-4715
Abdullah SarıhanDepartment of Cardiology, Gediz State Hospital, Kutahya, Turkey.
Macit KalçıkDepartment of Cardiology, Faculty of Medicine, Hitit University, Çorum, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This letter discusses methodological limitations of a retrospective case-control study evaluating HbA1c, HDL-C, and hemoglobin levels in microvascular angina. Although the findings are clinically interesting, differences in control phenotyping, incomplete CFR assessment, medication confounding, and endotype heterogeneity limit causal interpretation. Prospective, mechanism-based validation is needed before these variables are accepted as therapeutic targets.

Indexed as

Coronary flow reserveCoronary microvascular dysfunctionINOCAMicrovascular anginaRisk markers

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.