Evidence map›Paper›PMID 42402502›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026

Burden of early-onset laryngeal cancer in individuals aged 15-49 years: global, regional, and national estimates from the GBD 2021 study.

DuanShaLi Liu, YueHao Lu, BeiCheng Li, QingHua Liu, Ge Gao, ShiKang Zheng, Zhe Yang, XiaoHan Li, Kai Zhao, MingBo Liu

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

DuanShaLi LiuSchool of Clinical Medicine, Shandong Second Medical University, Weifang, 261000, China.
YueHao LuSchool of Clinical Medicine, Shandong Second Medical University, Weifang, 261000, China.
BeiCheng LiDepartment of Otolaryngology Head and Neck Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, 572013, China.
QingHua LiuMedical School of Chinese PLA, Beijing, 100853, China.
Ge GaoMedical School of Chinese PLA, Beijing, 100853, China.
ShiKang ZhengDepartment of Otolaryngology Head and Neck Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, 572013, China.
Zhe YangThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, China.
XiaoHan LiDepartment of Otolaryngology Head and Neck Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, 572013, China.
Kai ZhaoDepartment of Otolaryngology Head and Neck Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, 572013, China.
MingBo LiuSchool of Clinical Medicine, Shandong Second Medical University, Weifang, 261000, China. mingbo666@vip.163.com.ORCID http://orcid.org/0000-0002-0540-2573

Funding

Major Science and Technology Plan Project of Hainan Province ZDKJ202005Science and Technology Plan Project of Hainan Province LCYX202202Science and Technology Plan Project of Hainan Province LCYX202504
6 · The paper itself

Abstract

purposeEarly-onset laryngeal cancer remains understudied despite its potential clinical and socioeconomic impact in adolescents and adults of working age. We aimed to describe the global, regional, and national burden of laryngeal cancer among individuals aged 15-49 years using data from the Global Burden of Disease (GBD) 2021 study.

methodsData from the Global Burden of Disease (GBD) 2021 study were used to estimate incidence, mortality, disability-adjusted life years (DALYs), and attributable risk factors of laryngeal cancer among individuals aged 15-49 across 204 countries and territories from 1990 to 2021. Age-standardized rates (ASRs) and Joinpoint regression were applied to assess temporal trends, while associations with socio-demographic index (SDI) and risk factors were evaluated.

resultsIn 2021, early-onset laryngeal cancer accounted for 36,855 cases (ASR: 0.48/100,000), 19,550 deaths (ASR: 0.26/100,000), and 935,561 DALYs (ASR: 12.35/100,000) globally. The global age-standardized incidence rate (ASIR) in males was 4.39 times that in females. From 1990 to 2021, global age-standardized incidence and mortality generally declined, whereas incidence increased among females in Asia. Mortality and DALY rates were inversely associated with SDI, while incidence showed no significant correlation with SDI. Sulfuric acid exposure was the only factor associated with an increase in attributable mortality and DALYs over time, whereas smoking, alcohol use, and asbestos exposure showed declining attributable burdens.

conclusionAlthough the global burden of early-onset laryngeal cancer decreased from 1990 to 2021, marked sex- and region-specific disparities remained. Males bore a higher burden overall, and distinct regional patterns were observed, including a rising incidence among females in Asia. These findings provide a global descriptive overview of early-onset laryngeal cancer and may help inform future etiological research and region-specific prevention priorities. CLINICAL TRIAL NUMBER: not applicable.

Indexed as

Global Burden of DiseaseLaryngeal NeoplasmsAdolescentAdultAge of OnsetDisability-Adjusted Life YearsFemaleGlobal HealthHumansIncidenceMaleMiddle AgedRisk FactorsYoung AdultAge-standardized rateGlobal Burden of DiseaseLaryngeal cancerSocio-demographic index

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PMID42402502

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.