Evidence map›Paper›PMID 42402499›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026

Macrophage activation syndrome triggered by Candida parapsilosis-related cochlear implant infection.

Begum Bahar Yilmaz, Muhammed Talha Karadogan, Alper Tabaru, Figen Cakmak, Esra Sevketoglu, Sema Alacam, Ozgur Yigit

Abstract readCase Reports
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In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Begum Bahar YilmazOtorhinolaryngology and Head and Neck Surgery, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey. begumbahar.bbb@gmail.com.ORCID http://orcid.org/0000-0001-9521-9520
Muhammed Talha KaradoganPediatric Rheumatology, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.ORCID http://orcid.org/0000-0001-5588-0162
Alper TabaruOtorhinolaryngology and Head and Neck Surgery, Van Training Hospital, Van, Turkey.ORCID http://orcid.org/0000-0002-5835-1044
Figen CakmakPediatric Rheumatology, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-1667-2480
Esra SevketogluPediatric Intensive Care Unit, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-8330-2877
Sema AlacamMicrobiology and Clinical Microbiology, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.ORCID http://orcid.org/0000-0001-7957-2906
Ozgur YigitOtorhinolaryngology and Head and Neck Surgery, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.ORCID http://orcid.org/0000-0003-1731-3233

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCochlear implant-related infections may rarely lead to life-threatening systemic complications. Macrophage Activation Syndrome (MAS) is a severe and potentially fatal hyperinflammatory condition. MAS associated with CI infection has not been previously reported in pediatric patients. CASE PRESENTATION: We present a 13-year-old female patient who developed MAS secondary to Candida parapsilosis-related sepsis associated with cochlear implant (CI). Despite broad-spectrum antibacterial and antifungal therapy, the patient's clinical course deteriorated with pancytopenia, hyperferritinemia, and acute liver failure. She fulfilled HLH-2004 criteria and was diagnosed with MAS. Multidisciplinary treatment approach included plasmapheresis, high-dose pulse corticosteroids and CI explantation, resulted in clinical recovery. Implant site cultures revealed that Candida parapsilosis, a fungal pathogen known for biofilm formation and implant-related infections. Following explantation, the patient showed gradual improvement with immunosuppressive therapy and supportive care. Successful cochlear implant reimplantation was performed two months later.

conclusionCI-related infections and related systemic complications are rare but severe. This is the first reported pediatric case of MAS triggered by cochlear implant-related sepsis. Early recognition of MAS and multidisciplinary management are essential to improve outcome and survival.

Indexed as

Candida parapsilosisCandidiasisCochlear ImplantsMacrophage Activation SyndromeProsthesis-Related InfectionsAdolescentFemaleHumansBiofilm infectionCandida parapsilosisCochlear implantExplantationHemophagocytic lymphohistiocytosisImplant-related infectionMacrophage activation syndromePediatric

Identifiers

PMID42402499

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.