ReviewThe Journal of reproduction and development2026
Regulation of spermatozoal capacitation by serotonin.
Review in The Journal of reproduction and development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Mammalian spermatozoa begin swimming after ejaculation. After spermatozoa enter the oviduct, they undergo capacitation, penetrate the oocyte envelope, and fertilize the oocytes. These processes occur spontaneously but are influenced by hormones and neurotransmitters. Serotonin [5-hydroxytryptamine (5-HT)] is a well-known neurotransmitter found in reproductive organs. In the female reproductive system, serotonin is synthesized in the cumulus cells and affects steroidogenesis, oocyte maturation, fertilization, and embryo development. Recent studies have suggested that serotonin is also synthesized in spermatozoa and can affect motility, hyperactivation, acrosome reaction, and the success of in vitro fertilization (IVF) in hamsters, humans, mice, and rats. Importantly, the effects of serotonin on sperm function are dose-dependent, at least in hamsters, and serotonin concentrations in the female reproductive tract fluctuate during ovulation. The effects of serotonin on sperm function are mediated by 5-HT receptors (mainly 5-HT
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