ReviewBiotechnology and bioengineering2026
Rickettsial Diseases and Vaccines: Is There an Opportunity for Plant-Made Vaccine Technology?
Elizabeth Monreal-Escalante, Hassian León-Montoya, Abel Ramos-Vega, Edgar Trujillo, Miriam Angulo, Kevyn Guerra, Martha Reyes-Becerril, Carlos Angulo
Abstract readReview
In one paragraphReview in Biotechnology and bioengineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
Elizabeth Monreal-EscalanteImmunology & Vaccinology Group and Laboratorio Nacional CONAHCYT de Generación de Vacunas Veterinarias y Servicios de Diagnóstico (LNC-GVD), Centro de Investigaciones Biológicas del Noroeste, S.C. Instituto Politécnico Nacional 195, Playa Palo de Santa Rita Sur, La Paz, México.ORCID https://orcid.org/0000-0002-2798-6151 Hassian León-MontoyaImmunology & Vaccinology Group and Laboratorio Nacional CONAHCYT de Generación de Vacunas Veterinarias y Servicios de Diagnóstico (LNC-GVD), Centro de Investigaciones Biológicas del Noroeste, S.C. Instituto Politécnico Nacional 195, Playa Palo de Santa Rita Sur, La Paz, México.
Abel Ramos-VegaCentro de Investigación en Ciencia Aplicada y Tecnología Avanzada (CICATA) Unidad Morelos del Instituto Politécnico Nacional (IPN), Xochitepec, México.
Edgar TrujilloImmunology & Vaccinology Group and Laboratorio Nacional CONAHCYT de Generación de Vacunas Veterinarias y Servicios de Diagnóstico (LNC-GVD), Centro de Investigaciones Biológicas del Noroeste, S.C. Instituto Politécnico Nacional 195, Playa Palo de Santa Rita Sur, La Paz, México.
Miriam AnguloImmunology & Vaccinology Group and Laboratorio Nacional CONAHCYT de Generación de Vacunas Veterinarias y Servicios de Diagnóstico (LNC-GVD), Centro de Investigaciones Biológicas del Noroeste, S.C. Instituto Politécnico Nacional 195, Playa Palo de Santa Rita Sur, La Paz, México.ORCID https://orcid.org/0000-0002-0503-0108 Kevyn GuerraImmunology & Vaccinology Group and Laboratorio Nacional CONAHCYT de Generación de Vacunas Veterinarias y Servicios de Diagnóstico (LNC-GVD), Centro de Investigaciones Biológicas del Noroeste, S.C. Instituto Politécnico Nacional 195, Playa Palo de Santa Rita Sur, La Paz, México.
Martha Reyes-BecerrilImmunology & Vaccinology Group and Laboratorio Nacional CONAHCYT de Generación de Vacunas Veterinarias y Servicios de Diagnóstico (LNC-GVD), Centro de Investigaciones Biológicas del Noroeste, S.C. Instituto Politécnico Nacional 195, Playa Palo de Santa Rita Sur, La Paz, México.
Carlos AnguloImmunology & Vaccinology Group and Laboratorio Nacional CONAHCYT de Generación de Vacunas Veterinarias y Servicios de Diagnóstico (LNC-GVD), Centro de Investigaciones Biológicas del Noroeste, S.C. Instituto Politécnico Nacional 195, Playa Palo de Santa Rita Sur, La Paz, México.ORCID https://orcid.org/0000-0002-7965-1679 Funding
Centro de Investigaciones Biológicas del Noroeste PAZA-2026
6 · The paper itselfAbstract
Rickettsiosis is a zoonotic disease caused by obligate intracellular bacteria of the family Rickettsiae, transmitted by arthropods. No commercial vaccine exists, despite the efficacy of experimental prototypes based on whole cells, DNAs, nanosystems, and recombinant antigens. Plants have been used as a platform for producing and delivering recombinant antigens, allowing the commercial vaccines for COVID-19 and Influenza. This technology can be used for recombinant Rickettsia vaccines for the target host, potentially for vector arthropods. These aspects are reviewed in this work, considering a brief immunobiology of Rickettsiae, experimental vaccines against Rickettsiosis, step-by-step genetic engineering in plants for recombinant antigen production and immunological assessment, representative successful examples of plant-made vaccines, and the analysis of the potential of plant-made vaccines to control arthropod-transmitted Rickettsiae. Perspectives in this field are offered, highlighting hurdles and opportunities.
Indexed as
Plants, Genetically ModifiedRickettsiaRickettsia InfectionsRickettsial VaccinesAnimalsGenetic EngineeringHumansVaccines, SyntheticRickettsial VaccinesVaccines, Syntheticanimal healthhuman healthmolecular farmingOne Healthpreventive healthrecombinant antigens
Identifiers
PMID42402151
PMCPMC13576826
What OpenQuestion holds
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