Evidence map›Paper›PMID 42402032›Full record

ArticleJournal of virology2026

Magnolol inhibits porcine epidemic diarrhea virus infection by suppressing cathepsin L expression

Yi-Fan Liang, Xi Li, Gao-Xi Zhu, Yi Song, Xiong-Nan Chen, Heng Wang, Gui-Hong Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yi-Fan Liang *Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Xi Li *Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Gao-Xi ZhuKey Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, Beijing, China.
Yi SongGuangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Xiong-Nan ChenGuangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Heng WangGuangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.ORCID 0000-0001-8471-6337
Gui-Hong ZhangGuangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.ORCID 0000-0003-1236-1850

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Porcine epidemic diarrhea (PED), caused by the porcine epidemic diarrhea virus (PEDV), is an acute and highly contagious intestinal disease in pigs. The high variability of the PEDV S gene has rendered current commercial vaccines ineffective, indicating the need for safe, effective, and cost-effective antiviral agents to control PEDV. Here, we aimed to screen and identify compounds with anti-PEDV activity and elucidate the antiviral mechanisms of magnolol. A compound library was screened using an in-cell Western blotting assay to identify potential antiviral agents. The

Indexed as

Antiviral AgentsBiphenyl CompoundsCathepsin LCoronavirus InfectionsLignansPorcine epidemic diarrhea virusSwine DiseasesAnimalsCell LineChlorocebus aethiopsDeltacoronavirusSwineVero CellsVirus InternalizationAntiviral AgentsBiphenyl CompoundsCathepsin LLignansmagnololantiviral activitycoronavirus infectionCTSLintestinal epithelial cellsmagnololPEDV

Identifiers

PMID42402032
PMCPMC13386832

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.