Evidence map›Paper›PMID 42401874›Full record

ArticleBMC medicine2026

Social vulnerability index and inflammation: a proteomic analysis linking social context to biological risk in older black adults.

Anat Yaskolka Meir, Henry A Adeola, Shinya Tasaki, Liming Liang, Renã A S Robinson, Brittney S Lange-Maia, Melissa Lamar, Ana W Capuano, Lisa L Barnes

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Article in BMC medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Anat Yaskolka MeirDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Henry A AdeolaDepartment of Chemistry, Vanderbilt University, Nashville, TN, USA.
Shinya TasakiRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Liming LiangDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Renã A S RobinsonDepartment of Chemistry, Vanderbilt University, Nashville, TN, USA.
Brittney S Lange-MaiaRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Melissa LamarRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Ana W CapuanoDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Lisa L BarnesRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA. Lisa_L_Barnes@rush.edu.

Funding

NIA R01AG22018, P30AG10161, P30AG72975, R01AG064950, R01AG062711, R03AG071943NIA NIH HHS R01AG22018, P30AG10161, P30AG72975, R01AG064950, R01AG062711, R03AG071943
6 · The paper itself

Abstract

backgroundInflammation is a key driver of age-related disease and has been associated with social conditions. We examined how cumulative community-level social and structural disadvantage is associated with inflammatory proteomic profiles in older Black adults.

methodsWe employed data from the Minority Aging Research Study and the Rush Clinical Core, including the Social Vulnerability Index (SVI; global score and four domains) and 92 plasma inflammatory proteins (Olink® Target-96 Inflammation). Cross-sectional associations between each SVI metric and inflammatory proteins (principal component (PC)-derived global proteomic profile and protein-specific) were assessed using multivariable linear models (demographic, behavioral, and individual-level socioeconomic factors adjusted), with additional sex-by-SVI interaction terms. In a secondary analysis, we replaced SVI with the Index of Concentration at the Extremes (ICE) for household income (ICE

resultsA total of 580 participants (mean (SD) age of 74.9 (6.50) years; 79.7% women) had global SVI and proteomics assessed. Lower household composition (SVI

conclusionsBy analyzing associations between community-level factors and inflammation-related proteins, our study provides new molecular insights into how social context may relate to biological risk, identifies proteomic patterns that could inform the development of community-level interventions, and underscores the utility of integrating multi-omics approaches to investigate biological pathways relevant to health disparities research.

Indexed as

Black or African AmericanInflammationProteomicsSocial VulnerabilityAgedAged, 80 and overCross-Sectional StudiesFemaleHumansMaleRisk FactorsSocioeconomic Disparities in HealthSocioeconomic FactorsIncome disparitiesInflammatory proteinsStructural disadvantage

Identifiers

PMID42401874

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.