SynthesisBMC endocrine disorders2026
Serum anti-Müllerian hormone levels in women following bariatric surgery: insights from a systematic review and meta-analysis.
Synthesis in BMC endocrine disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
aimThis systematic review and meta-analysis aimed to evaluate the effects of bariatric surgery on serum anti-Müllerian hormone (AMH) levels in women, highlighting potential implications for ovarian reserve and fertility management.
methodsA systematic literature search was conducted in PubMed, Web of Science, Scopus, and Embase databases up to February 2025. The included studies were observational in design (cohort, case-control, cross-sectional) and provided quantitative pre- and post-operative AMH data. Quality assessment was performed using the Newcastle-Ottawa Scale, and data were analyzed using a random-effects meta-analysis.
resultsA total of 14 studies were included in the systematic review, with 591 participants contributing to the quantitative meta-analysis. The pooled results indicated that bariatric surgery did not significantly alter AMH levels overall (WMD = 0.05 ng/mL; 95% CI: -0.66, 0.75; p = 0.897), with substantial heterogeneity among effect estimates (I² = 93.9%, p < 0.001). Subgroup analyses suggested significant AMH reductions in studies with baseline AMH > 3 ng/mL, upper age limit ≤ 35 years, longer follow-up, retrospective design, smaller sample size, and South Asian populations, while a significant increase was observed in the fertile subgroup.
conclusionsBariatric surgery was not associated with a significant overall change in serum AMH levels. Findings suggest variable AMH responses across clinical and methodological contexts; however, given substantial heterogeneity and limited reproductive outcome data, these changes should be interpreted as dynamic endocrine biomarker responses rather than direct evidence of altered ovarian reserve or fertility potential. CLINICAL TRIAL NUMBER: Not applicable.
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