Evidence map›Paper›PMID 42401784›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2026

Spleen-associated macrophage alterations and embryo viability in a murine model of recurrent spontaneous abortion.

Kang Zhu, Hailong Zhang, Sijia Chen, Xi Deng, Xi Chen, Dan Wan, Mengchen Zhu, Chen Zhang, Yane Gao

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Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Kang ZhuDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Hailong ZhangNational-Local Joint Engineering Research Center of Biodiagnostics & Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Sijia ChenNational-Local Joint Engineering Research Center of Biodiagnostics & Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Xi DengNational-Local Joint Engineering Research Center of Biodiagnostics & Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Xi ChenInstitute of Tumor and Immunology, Precision Medicine Research Institute, Xi'an Jiaotong University, Xi'an, 712000, China.
Dan WanNational-Local Joint Engineering Research Center of Biodiagnostics & Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Mengchen ZhuNational-Local Joint Engineering Research Center of Biodiagnostics & Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Chen ZhangNational-Local Joint Engineering Research Center of Biodiagnostics & Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Yane GaoDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China. gaoyane@xjtu.edu.cn.

Funding

the Key Research and Development Projects of Shaanxi Province No. 2025SF-YBXM-396
6 · The paper itself

Abstract

backgroundRecurrent spontaneous abortion (RSA) is commonly attributed to immune dysregulation at the maternal-fetal interface. The contribution of the spleen, as a peripheral immune organ, remains unclear. This study investigated spleen-associated immune alterations in a murine model of RSA.

methodsAn RSA model was established by mating CBA/J females with DBA/2 males. Splenic and decidual immune-cell distributions were assessed by histology, flow cytometry, and cytokine analysis. Splenectomy and macrophage depletion were performed as experimental interventions. Decidual transcriptomic changes following splenectomy were analyzed by bulk RNA sequencing and transcriptomic enrichment analyses.

resultsRSA mice exhibited splenomegaly, altered splenic histological features, and changes in splenic immune-cell composition, including increased numbers of Ly6C

conclusionThese findings identify an association between spleen-associated immune alterations and RSA and suggest that splenectomy is accompanied by changes in decidual immune-cell distributions, tissue-level transcriptional patterns, and embryo viability.

Indexed as

Abortion, HabitualMacrophagesSpleenAnimalsCytokinesDeciduaDisease Models, AnimalFemaleMaleMiceMice, Inbred CBAMice, Inbred DBAPregnancySplenectomyTranscriptomeCytokinesDecidual immune alterationsMacrophage depletionRecurrent spontaneous abortionSpleen-associated macrophagesSplenectomy

Identifiers

PMID42401784

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.