Evidence map›Paper›PMID 42401755›Full record

ArticleEMBO molecular medicine2026

Foxs1-mediated transformation of CD34

Junyao Yang, Ting Chen, Run Zhang, Jing Xu, Xinghe Zhao, Mei Yang, Zheyi Chen, Shasha Sun, Xiaocui Chen, Shuqiong Zhang and 7 more

Abstract read
In one paragraph

Article in EMBO molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Junyao Yang *Department of Laboratory Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0003-3307-704X
Ting Chen *Department of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0000-0002-9723-9020
Run Zhang *Department of Cardiology and Institute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.ORCID http://orcid.org/0009-0001-4067-0880
Jing XuDepartment of Pediatric Orthopedics, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xinghe ZhaoDepartment of Laboratory Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Mei YangDepartment of Cardiology and Institute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Zheyi ChenDepartment of Laboratory Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shasha SunDepartment of Cardiology and Institute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Xiaocui ChenDepartment of Laboratory Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shuqiong ZhangDepartment of Laboratory Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Liujun JiangDepartment of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0000-0001-6961-8552
Yingxia ZhengDepartment of Laboratory Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yanhua HuDepartment of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Qingbo XuDepartment of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Wei LinState Key Laboratory for Oncogenes and Related Genes, Department of Cardiology, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China. 21520@renji.com.ORCID http://orcid.org/0000-0002-7506-3466
Lisong ShenDepartment of Laboratory Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. shenlisong@xinhuamed.com.cn.
Li ZhangDepartment of Cardiology and Institute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China. li.zhang@shsmu.edu.cn.ORCID http://orcid.org/0000-0002-6906-3275

Funding

MOST | National Key Research and Development Program of China (NKPs) 2022YFA1104200MOST | National Natural Science Foundation of China (NSFC) 81672363MOST | National Natural Science Foundation of China (NSFC) 81800364MOST | National Natural Science Foundation of China (NSFC) 81802082MOST | National Natural Science Foundation of China (NSFC) 81870206MOST | National Natural Science Foundation of China (NSFC) 81930010MOST | National Natural Science Foundation of China (NSFC) 82100503MOST | National Natural Science Foundation of China (NSFC) 82125005MOST | National Natural Science Foundation of China (NSFC) W2411082Shanghai Jiao Tong University (SJTU) YG2025QNB48Shanghai Municipal Health Commission ( ) 202440197STCSM | Natural Science Foundation of Shanghai Municipality ( ) 25ZR1402361
6 · The paper itself

Abstract

Cancer-associated fibroblasts (CAFs) represent a major structural component of solid tumors and play crucial roles in cancer progression and drug resistance. However, their developmental origin, differentiation trajectory, and therapeutic potential remain poorly defined. Using advanced approaches-including inducible genetic lineage tracing, single-cell RNA sequencing, and spatial transcriptomic profiling-we identified a population of Cd34

Indexed as

Antigens, CD34Cancer-Associated FibroblastsCell Transformation, NeoplasticForkhead Transcription FactorsMelanomaAnimalsCell DifferentiationGene Expression ProfilingHumansMiceAntigens, CD34Forkhead Transcription Factors

Identifiers

PMID42401755
PMCPMC13469093

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.