Valorization of Moringa oleifera pericarp via semi-synthetic sugar-based enone derivatives with anticancer potential: phytochemical isolation, cytotoxic evaluation, and dual EGFR/CAIX targeting.

Mayye Majed, Amal A Galala, Dina I A Othman, Mohamed M Amer, Sara Abouzeid

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mayye MajedPharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.

Amal A GalalaPharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.

Dina I A OthmanDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.

Mohamed M AmerPharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.

Sara AbouzeidPharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. sara86@mans.edu.eg.ORCID 0000-0001-5843-7772

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Moringa oleifera pericarp, an underutilized agro-waste, was investigated as a potential source of anticancer agents. In this study, bioassay-guided fractionation of the pericarp extract led to the identification of the ethyl acetate fraction as the most active fraction, showing notable antioxidant, antimicrobial, and cytotoxic activities. Subsequent purification afforded three compounds: 4-(α-L-rhamnopyranosyloxy)-benzaldehyde (M

Indexed as

Antineoplastic AgentsAntineoplastic Agents, PhytogenicCarbonic Anhydrase IXMoringa oleiferaPhytochemicalsPlant ExtractsAntigens, NeoplasmErbB ReceptorsHCT116 CellsHep G2 CellsHumansMolecular Docking SimulationAntigens, NeoplasmAntineoplastic AgentsAntineoplastic Agents, PhytogenicCA9 protein, humanCarbonic Anhydrase IXEGFR protein, humanErbB ReceptorsPhytochemicalsPlant Extractsagro-wasteanticancer activityCAIXEGFR-TKMoringa oleiferasemi-synthesis

Identifiers

PMID42401652

DOI10.1038/s41598-026-59686-2

PMCPMC13333019

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.