Evidence map›Paper›PMID 42401582›Full record

ArticleNature communications2026

metilene

Zhihan Zhu, Stephan H Bernhart, Frank Jühling, Helene Kretzmer, Steve Hoffmann

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhihan ZhuMax Planck Institute for Molecular Genetics, Berlin, Germany.ORCID 0000-0003-3779-4265
Stephan H BernhartLeiCeM - Leipzig Center of Metabolism, Leipzig University, Leipzig, Germany.ORCID 0000-0002-5928-9449
Frank JühlingUniversity of Strasbourg, Inserm, Institute for Translational Medicine and Liver Disease (ITM), UMR_S1110, Strasbourg, France.
Helene KretzmerMax Planck Institute for Molecular Genetics, Berlin, Germany. helene.kretzmer@hpi.de.ORCID 0000-0002-0723-4980
Steve HoffmannDepartment of Mathematics and Computer Science, Free University Berlin, Berlin, Germany. steve.hoffmann@leibniz-fli.de.ORCID 0000-0002-5239-7201

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) EXC-3105/1 - 533765739
6 · The paper itself

Abstract

DNA methylation is a critical epigenetic mark across numerous species, and identifying differentially methylated regions (DMRs) is essential for understanding genome regulation. Most existing DMR detection methods require predefined sample conditions, limiting the discovery of new epigenetic patterns, especially when group identities are unknown or uncertain, as is common in clinical settings. Additionally, only a very few approaches enable comparisons across multiple conditions. To address this significant gap, we present metilene

Indexed as

DNA MethylationEpigenesis, GeneticHumansPancreatic Neoplasms

Identifiers

PMID42401582
PMCPMC13333024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.