ArticleNature communications2026
Glutamatergic signaling underlies brain structural organization for mathematical and reading abilities in children.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Glutamatergic signaling underlies brain structural organization for mathematical and reading abilities in children.Nature communications · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The neurochemical mechanisms underlying individual differences in children's mathematical and reading abilities remain largely unknown. Here we investigate how neurotransmitter systems relate to brain structural organization supporting these abilities in two independent cohorts of children (N = 991). We mapped brain-wide structural phenotypes associated with academic performance onto a comprehensive PET atlas of 19 neurotransmitter receptors and transporters. Across both domains and cohorts, NMDA glutamatergic receptor distribution showed the most consistent associations with brain structural organization supporting academic abilities (replication Bayes factors >9e4 for mathematics; >4 for reading). NMDA receptor density corresponded with multiple functional networks for mathematical abilities but showed more spatially focused associations within visual networks for reading, suggesting both shared and domain-specific neurochemical mechanisms. Dopaminergic, cholinergic, serotonergic, and GABAergic systems showed weaker, non-replicable associations. These findings bridge molecular neurochemistry and macro-scale brain architecture supporting academic skills, identifying glutamatergic signaling as a candidate target for interventions addressing learning disabilities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.