Evidence map›Paper›PMID 42401380›Full record

ArticleActa biomaterialia2026

Colorectum and embedded networks of nerve fibers present auxetic responses during uniaxial circumferential extension.

Amirhossein Shokrani, Atta Seck, Kazunori Hoshino, Ming-Hui Chen, Bin Feng, David M Pierce

Abstract read
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In one paragraph

Article in Acta biomaterialia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Amirhossein ShokraniSchool of Aerospace, Manufacturing, and Mechanical Engineering, University of Connecticut, Storrs, CT, USA.
Atta SeckDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.
Kazunori HoshinoDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.
Ming-Hui ChenDepartment of Statistics, University of Connecticut, Storrs, CT, USA.
Bin FengDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, USA. Electronic address: fengb@uconn.edu.
David M PierceSchool of Aerospace, Manufacturing, and Mechanical Engineering, University of Connecticut, Storrs, CT, USA; Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA. Electronic address: david.pierce@uconn.edu.

Funding

Determining the topology and molecular profiles of nociceptive DRG neurons innervating distal colon and rectumU01NS113873 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI FENG, BIN · 2019 to 2021
$2.0M
The Role of Lumbar Splanchnic Innervations in Visceral Nociception and PainR01DK120824 · NIDDK · UNIVERSITY OF CONNECTICUT STORRS · PI FENG, BIN · 2019 to 2023
$2.0M
NIDDK NIH HHS R01 DK120824NINDS NIH HHS U01 NS113873
6 · The paper itself

Abstract

Understanding the multiscale mechanics of the colorectum is essential for uncovering the mechanotransductive pathways underlying visceral nociception. Intraluminal distension of the large intestine reliably evokes pain in disorders of gut-brain interaction (DGBIs), yet the tissue-level and nerve fiber-level responses to mechanical loading remain poorly defined. Here, we present results from our new biomechanical testing framework that integrates uniaxial circumferential extension with high-resolution optical imaging to quantify deformation in both bulk colorectal tissue and embedded sensory nerve fibers. We tested intact, cylindrical colorectal segments from mice using intraluminal stainless-steel rods to apply circumferential stretch while maintaining a planar imaging field. We measured bulk-tissue deformation via Digital Image Correlation (DIC), while we assessed stretch in nerve fibers through fluorescence imaging of VGLUT2-labeled afferents analyzed using custom fiber-network analyses. We tested our null hypothesis that the Poisson's function was greater than zero, i.e. ν

Indexed as

ColonNerve FibersRectumAnimalsBiomechanical PhenomenaMaleMechanotransduction, CellularMiceMice, Inbred C57BLStress, MechanicalAuxetic soft tissueColonDisorders of gut-brain interactionsMechanotransductionRectumVisceral pain

Identifiers

PMID42401380
PMCPMC13595332

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.