ArticleMolecular pharmacology2026
Regulation of organic anion transporting polypeptide 1B1 transport function by lysine deacetylase 6.
Vikram Aditya, Vishakha Tambe, Pascaline Niyonshuti, Ruhul Kayesh, Erik J Soderblom, Xiaohong Mary Zhang, Chao Xu, Wei Yue
Abstract read
In one paragraphArticle in Molecular pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
8 authors.
Vikram AdityaDepartment of Pharmaceutical Sciences, University of Oklahoma Health Campus, Oklahoma City, Oklahoma.
Vishakha TambeDepartment of Pharmaceutical Sciences, University of Oklahoma Health Campus, Oklahoma City, Oklahoma.
Pascaline NiyonshutiDepartment of Pharmaceutical Sciences, University of Oklahoma Health Campus, Oklahoma City, Oklahoma.
Ruhul KayeshDepartment of Pharmaceutical Sciences, University of Oklahoma Health Campus, Oklahoma City, Oklahoma.
Erik J SoderblomProteomics and Metabolomics Core Facility, Duke University School of Medicine, Durham, North Carolina.
Xiaohong Mary ZhangDepartment of Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.
Chao XuDepartment of Biostatistics and Epidemiology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma.
Wei YueDepartment of Pharmaceutical Sciences, University of Oklahoma Health Campus, Oklahoma City, Oklahoma. Electronic address: wei-yue@ou.edu.
Funding
Tissue Pathology Shared ResourceP30CA225520 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI James F Papin · 2018 to 2026
$27.1MFV 10i-LIV Conofocal Imaging System (GM094268)R01GM094268 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YUE, WEI · 2011 to 2015
$1.5MRegulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitorsR01GM146956 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI YUE, WEI · 2022 to 2025
$1.3MThermo Lumos Tribrid High-Resolution Accurate-Mass Tandem Mass SpectrometerS10OD024999 · OD · DUKE UNIVERSITY · PI MOSELEY, MARTIN ARTHUR · 2018 to 2018
$600kTargeting USP10 to regulate the DNA damage response in NSCLCR21CA256423 · NCI · WAYNE STATE UNIVERSITY · PI BEPLER, GEROLD, ZHANG, XIAOHONG MARY · 2021 to 2022
$392kNCI NIH HHS P30 CA225520NCI NIH HHS R21 CA256423NIGMS NIH HHS R01 GM094268NIGMS NIH HHS R01 GM146956NIH HHS S10 OD024999
6 · The paper itselfAbstract
Hepatic transport protein organic anion transporting polypeptide 1B1 (OATP1B1) is a key determinant of drug-drug interactions. We reported OATP1B1 lysine acetylation recently, however, the lysine deacetylase (KDAC), also known as histone deacetylase (HDAC), involved in its deacetylation remains uninvestigated. This study determined the role of KDAC6/HDAC6, a major cytosolic KDAC, on OATP1B1 acetylation and transport function. Loss-of-function of KDAC6 by CRISPR/Cas9-mediated knockout in HEK293T cells or by treatment with the selective KDAC6 inhibitor tubacin (TBC) (5 μM, 24 hours) in transporter-expressing HEK293 cells markedly reduces OATP1B1-mediated transport of [
Indexed as
Histone Deacetylase 6Liver-Specific Organic Anion Transporter 1AcetylationAnilidesBiological TransportEstradiolHEK293 CellsHumansHydroxamic AcidsLysineProtein Processing, Post-TranslationalAnilidesEstradiolestradiol-17 beta-glucuronideHDAC6 protein, humanHistone Deacetylase 6Hydroxamic AcidsLiver-Specific Organic Anion Transporter 1LysineSLCO1B1 protein, humantubacinDrug–drug interactionDrug transportersLysine acetylationLysine/Histone deacetylase 6OATP1B1Phosphorylation
Identifiers
PMID42401032
PMCPMC13421777
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