Evidence map›Paper›PMID 42400886›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2026

Harnessing Silicene-to-Silicic Acid Conversion for Organelle-Specific Silica Deposition in Tumor Therapy.

Tongyi Shang, Changming You, Jinhui Zhao, Aiwei Wang, Jiaqi Shen, Yuanru Zhu, Junxian Yang, Kai Xiao, Wei Sun, Yi Ma and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tongyi ShangGuangdong Engineering Research Center of Low-Carbon Synthetic Biotechnology, State Key Laboratory of Pulp and Paper Engineering, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, P. R. China.
Changming YouGuangdong Provincial Key Laboratory of Allergy and Clinical Immunology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, P. R. China.
Jinhui ZhaoGuangdong Engineering Research Center of Low-Carbon Synthetic Biotechnology, State Key Laboratory of Pulp and Paper Engineering, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, P. R. China.
Aiwei WangProteomics Research Center, Core Facility of Instrument, School of Basic Medicine Peking Union Medical College, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, Beijing, P. R. China.
Jiaqi ShenGuangdong Provincial Key Laboratory of Allergy and Clinical Immunology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, P. R. China.
Yuanru ZhuGuangdong Engineering Research Center of Low-Carbon Synthetic Biotechnology, State Key Laboratory of Pulp and Paper Engineering, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, P. R. China.
Junxian YangGuangdong Engineering Research Center of Low-Carbon Synthetic Biotechnology, State Key Laboratory of Pulp and Paper Engineering, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, P. R. China.
Kai XiaoGuangdong Engineering Research Center of Low-Carbon Synthetic Biotechnology, State Key Laboratory of Pulp and Paper Engineering, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, P. R. China.
Wei SunProteomics Research Center, Core Facility of Instrument, School of Basic Medicine Peking Union Medical College, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, Beijing, P. R. China.
Yi MaGuangdong Engineering Research Center of Low-Carbon Synthetic Biotechnology, State Key Laboratory of Pulp and Paper Engineering, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, P. R. China.ORCID https://orcid.org/0000-0002-7582-3429
Wei ZhuGuangdong Engineering Research Center of Low-Carbon Synthetic Biotechnology, State Key Laboratory of Pulp and Paper Engineering, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, P. R. China.ORCID https://orcid.org/0000-0003-3240-6905
Qi LeiGuangdong Provincial Key Laboratory of Allergy and Clinical Immunology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, P. R. China.ORCID https://orcid.org/0000-0001-6246-8352

Funding

Guangdong Key Areas R&D Program 2022B1111080007Guangdong S&T Program 2024B1111130002Guangzhou Science and Technology Plan Project 2024A03J0163Guangzhou Science and Technology Plan Project 2024A04J3029National Natural Science Foundation of China 22372061National Natural Science Foundation of China 22572061
6 · The paper itself

Abstract

Inducing localized mineralized lesions offers a promising drug-free strategy for tumor suppression, yet calcium-phosphate systems are limited by slow crystallization, high ion requirements, and poor organelle specificity. Here, we develop a silicene-derived nanoplatform that serves as an "inorganic silicic acid reservoir", enabling controlled, organelle-specific biosilicification for cancer therapy. Silicene nanosheets are sequentially engineered with tannic acid and PEI-anchored triphenylphosphonium (TPTS), conferring high colloidal stability, efficient endosomal escape, and selective mitochondrial targeting. Within the oxidative mitochondrial milieu, TPTS undergoes programmed hydrolysis to release Si(OH)

Indexed as

Antineoplastic AgentsOrganellesSilicic AcidSilicon DioxideAnimalsApoptosisCell Line, TumorHumansMiceMitochondriaAntineoplastic AgentsSilicic AcidSilicon Dioxidebiosilicificationmineralization therapymitochondria‐targetingsilicenesilicic acid reservoir

Identifiers

PMID42400886
PMCPMC13449160

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.