ArticleApoptosis : an international journal on programmed cell death2026
Taginostat, a new quinolone-based HDAC6 inhibitor, promotes apoptosis of chronic lymphocytic leukemia cells in vitro and in vivo by activating STAT4.
Vanessa Tatangelo, Gabriele Carullo, Ludovica Lopresti, Cristina Ulivieri, Simone Brogi, Stefania Butini, Matteo Gatta, Nagaja Capitani, Federica Rungo, Maria Carmela Cavallo and 8 more
Abstract read
In one paragraphArticle in Apoptosis : an international journal on programmed cell death, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
18 authors.
Vanessa Tatangelo *Department of Life Sciences, University of Siena, Via Aldo Moro 2, Siena, 53100, Italy.ORCID 0000-0002-4572-4737 Gabriele Carullo *Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, Siena, 53100, Italy.ORCID 0000-0002-1619-3295 Ludovica LoprestiDepartment of Life Sciences, University of Siena, Via Aldo Moro 2, Siena, 53100, Italy.ORCID 0000-0001-9510-9284 Cristina UlivieriDepartment of Life Sciences, University of Siena, Via Aldo Moro 2, Siena, 53100, Italy.ORCID 0000-0002-1710-7977 Stefania ButiniDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, Siena, 53100, Italy.ORCID 0000-0002-8471-0880 Nagaja CapitaniDepartment of Life Sciences, University of Siena, Via Aldo Moro 2, Siena, 53100, Italy.ORCID 0000-0003-3653-8972 Federica RungoDepartment of Life Sciences, University of Siena, Via Aldo Moro 2, Siena, 53100, Italy.ORCID 0000-0003-1836-960X Maria Carmela CavalloDepartment of Life Sciences, University of Siena, Via Aldo Moro 2, Siena, 53100, Italy.ORCID 0009-0004-0219-6315 Alessandro GozzettiHaematology Unit, Department of Medical Sciences, Surgery and Neuroscience, University of Siena, Policlinico "Santa Maria alle Scotte", Viale Bracci, Siena, 53100, Italy.ORCID 0000-0003-0769-6891 Monica BocchiaHaematology Unit, Department of Medical Sciences, Surgery and Neuroscience, University of Siena, Policlinico "Santa Maria alle Scotte", Viale Bracci, Siena, 53100, Italy.ORCID 0000-0003-3538-3913 Monica TozziStem Cell Transplant and Cellular Therapy Unit, University Hospital, Policlinico "Santa Maria alle Scotte", Viale Bracci, Siena, 53100, Italy.ORCID 0009-0000-4578-728X Sara CiofiniHaematology Unit, Department of Medical Sciences, Surgery and Neuroscience, University of Siena, Policlinico "Santa Maria alle Scotte", Viale Bracci, Siena, 53100, Italy.ORCID 0009-0007-5623-1288 Sandra GemmaDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, Siena, 53100, Italy.ORCID 0000-0002-8313-2417 Cosima T Baldari *Department of Life Sciences, University of Siena, Via Aldo Moro 2, Siena, 53100, Italy.ORCID 0000-0002-4414-6744 Giuseppe Campiani *Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, Siena, 53100, Italy.ORCID 0000-0001-5295-9529 Laura Patrussi *Department of Life Sciences, University of Siena, Via Aldo Moro 2, Siena, 53100, Italy. patrussi2@unisi.it.ORCID 0000-0003-1542-6955 Funding
European Research Council Grant Agreement ERC 951329Fondazione AIRC per la ricerca sul cancro ETS IG 2017 - ID. 20148Ministero dell'Università e della Ricerca Project Code ECS_00000017 MUR Directoral Decree n.1055, 23 June 2022, CUP B83C22003930001Regione Toscana PRECISE-CLL
6 · The paper itselfAbstract
Chronic lymphocytic leukemia (CLL) is a hematological malignancy characterized by the accumulation of mature CD5⁺ B cells largely due to defective apoptosis. Prolonged leukemic cell survival has been linked to downregulation of the pro-apoptotic adaptor p66Shc and its transcription factor STAT4, both of which are typically reduced in CLL patients. To date, a clear mechanistic explanation for STAT4 deficiency in CLL has not yet been provided. Restoring STAT4 expression or activating its residual function may represent an attractive therapeutic strategy. Histone deacetylase 6 (HDAC6) directly deacetylates and suppresses STAT4 in T lymphocytes, suggesting that a similar mechanism may operate in CLL cells. In this study, we hypothesized that HDAC6-mediated STAT4 inhibition also occurs in CLL cells and contributes to leukemic cell survival. Accordingly, we tested the potent HDAC6 inhibitor Taginostat (HDAC6 IC
Indexed as
Antineoplastic AgentsApoptosisHistone Deacetylase InhibitorsHydroxamic AcidsLeukemia, Lymphocytic, Chronic, B-CellSTAT4 Transcription FactorAnimalsCell Line, TumorHistone Deacetylase 6HumansMiceShc Signaling Adaptor ProteinsSrc Homology 2 Domain-Containing, Transforming Protein 1Antineoplastic AgentsHDAC6 protein, humanHistone Deacetylase 6Histone Deacetylase InhibitorsHydroxamic AcidsShc Signaling Adaptor ProteinsSrc Homology 2 Domain-Containing, Transforming Protein 1STAT4 Transcription FactorapoptosisCLLHDAC6 inhibitorp66ShcSTAT4
What OpenQuestion holds
Textmetadata
Read underepoch 390