Evidence map›Paper›PMID 42400828›Full record

ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2026

Iron-ascorbate complex formation and redox behavior in Tris buffer under aerobic and anaerobic conditions: relevance to iron-deficiency anemia.

Manmeet Singh, Jayanta Bag, Manas Khatua, Biplab K Maiti

Abstract read
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Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Manmeet SinghSchool of Sciences, Department of Chemistry, Cluster University of Jammu, Canal Rd, Jammu and Kashmir, 180001, Jammu, India.
Jayanta BagDepartment of Chemistry, Indian Institute of Science Education and Research Tirupati, Tirupati, 517619, Andhra Pradesh, India.
Manas KhatuaCentral Instrumentation Facility, Indian Institute of Technology (IIT) Jammu, Paloura, Jammu & Kashmir, 181121, Jammu, India.
Biplab K MaitiSchool of Sciences, Department of Chemistry, Cluster University of Jammu, Canal Rd, Jammu and Kashmir, 180001, Jammu, India. biplabmaiti@clujammu.ac.in.

Funding

DST -SERB CRG/2022/005673DST-SERB CRG/2022/005673
6 · The paper itself

Abstract

Iron-ascorbate (Fe-Asc) is a clinically approved drug for iron-deficiency anemia (IDA), yet its formation and redox behavior under varying conditions remain poorly understood. Herein, we report the first comprehensive examination of Fe-Asc formation and redox reactivity in Tris buffer as a function of stoichiometry, pH, and oxygen availability. Oxidation of Fe(II) in air-saturated buffer accelerates with pH, yielding multiple species, primarily di- and tri-nuclear clusters. Notably, FeSO₄ with AscH produces a distinct purple complex (λ

Indexed as

Ascorbic AcidFerrous CompoundsIronTromethamineAerobiosisAnaerobiosisBuffersHydrogen-Ion ConcentrationOxidation-ReductionOxygenAscorbic AcidBuffersFerrous CompoundsIronOxygenTromethamineIron-ascorbateIron deficiency anaemiapH and oxygen availabilityRedox interplay

Identifiers

PMID42400828

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.