Evidence map›Paper›PMID 42400808›Full record

ArticleMolecular and cellular biochemistry2026

Chlamydia psittaci induces GSDME-mediated pyroptosis via the ROS-JNK signaling pathway.

Cui Xiao, Canming Hu, Zhe Liu, Gang Wang, Chuan Wang, Zhongyu Li, Qinqin Bai, Shenghua Chen, Lili Chen

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cui XiaoDepartment of public health laboratory sciences, School of public health, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Canming HuDepartment of public health laboratory sciences, School of public health, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Zhe LiuDepartment of public health laboratory sciences, School of public health, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Gang WangGuangzhou Tianhe District People's Hospital, Guangzhou, 510000, China.
Chuan WangSchool of Basic Medicine, Hengyang medical school, University of South China, Hengyang, Hunan, China.
Zhongyu LiSchool of Basic Medicine, Hengyang medical school, University of South China, Hengyang, Hunan, China.
Qinqin BaiDepartment of public health laboratory sciences, School of public health, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Shenghua ChenSchool of Basic Medicine, Hengyang medical school, University of South China, Hengyang, Hunan, China. chenshenghuaa@163.com.
Lili ChenDepartment of public health laboratory sciences, School of public health, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China. chlili720612@163.com.

Funding

National Natural Science Foundation of China 82402661Natural Science Foundation of Hunan Province 2023JJ30502Scientific Research Fund of Hunan Provincial Education Department 20A438, 22B0417
6 · The paper itself

Abstract

Chlamydia psittaci is an obligate intracellular zoonotic pathogen that causes atypical pneumonia. Pyroptosis is a type of regulated cell death mediated by gasdermin-family proteins and plays an important role in the response to intracellular infection. This study investigates whether C. psittaci infection triggers GSDME-mediated pyroptosis through the ROS-JNK signaling pathway. Our study revealed that infection with C. psittaci induces pyroptosis through caspase-3 activation and subsequent GSDME cleavage in human cervical epithelial (HeLa) cells. Mechanistically, the infection increased intracellular levels of reactive oxygen species (ROS) and phosphorylated c-Jun N-terminal kinase (JNK). Treatment with either the ROS scavenger NAC or the JNK inhibitor SP600125 significantly suppressed pyroptosis. Furthermore, inhibition of either the caspase-3-GSDME axis or the ROS-JNK pathway significantly increased the number of C. psittaci inclusion bodies. Taken together, our findings suggest that the ROS/JNK signaling pathway modulates GSDME-mediated pyroptosis and concurrently restricts C. psittaci replication in host cells, identifying the ROS-JNK-GSDME axis as a key mechanism in C. psittaci-induced pyroptosis. These findings reveal novel therapeutic targets for the treatment of psittacosis.

Indexed as

Chlamydophila psittaciJNK Mitogen-Activated Protein KinasesMAP Kinase Signaling SystemPhosphate-Binding ProteinsPsittacosisPyroptosisReactive Oxygen SpeciesReceptors, EstrogenGasderminsHeLa CellsHumansGasderminsGSDME protein, humanJNK Mitogen-Activated Protein KinasesPhosphate-Binding ProteinsReactive Oxygen SpeciesReceptors, EstrogenChlamydia psittaciGSDMEJNKPyroptosisROS

Identifiers

PMID42400808

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.