Evidence map›Paper›PMID 42400798›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Chimeric RNAs as Novel Neoantigens for Extracellular Vesicles-Based Vaccines Against Cancer.

Mengyuan Hu, Xiaona Lin, Huiying Huang, Yuhua Meng, Hao Zhang

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mengyuan Hu *Jinan University Affiliated Guangzhou Red Cross Hospital, Jinan University, Guangzhou, Guangdong, China.
Xiaona Lin *State Key Laboratory of Bioactive Molecules and Druggability Assessment, MOE Key Laboratory of Tumor Molecular Biology and Institute of Precision Cancer Medicine and Pathology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
Huiying HuangJinan University Affiliated Guangzhou Red Cross Hospital, Jinan University, Guangzhou, Guangdong, China.
Yuhua MengState Key Laboratory of Bioactive Molecules and Druggability Assessment, MOE Key Laboratory of Tumor Molecular Biology and Institute of Precision Cancer Medicine and Pathology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
Hao ZhangJinan University Affiliated Guangzhou Red Cross Hospital, Jinan University, Guangzhou, Guangdong, China. haolabcancercenter@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor vaccines largely depend on targetable tumor-specific neoantigens. However, in certain tumors, mutation-based neoantigens are exceptionally rare or even absent. To address this challenge, we developed an innovative strategy beyond genomic mutation events by utilizing tumor-specific chimeric RNAs and their encoded chimeric proteins. In this study, we demonstrated through flow cytometry and cell counting kit-8 (CCK-8) assays that aberrantly spliced tumor-specific chimeric RNAs (e.g., the ASTN2-PAPPA antisense chimeric RNA, A-PaschiRNA) can serve as tumor neoantigens. Furthermore, utilizing mouse tumorigenesis models, we have developed a novel therapeutic strategy involving extracellular vesicle (EV)-based vaccines loaded with chimeric RNAs to treat esophageal squamous cell carcinoma.

Indexed as

Antigens, NeoplasmCancer VaccinesEsophageal NeoplasmsExtracellular VesiclesAnimalsCell Line, TumorEsophageal Squamous Cell CarcinomaFlow CytometryHumansMiceAntigens, NeoplasmCancer VaccinesAberrantly spliced chimeric RNAASTN2-PAPPA antisense chimeric RNACell counting kit-8 (CCK-8)Esophageal squamous cell carcinomaExtracellular vesicle-based tumor vaccineFlow cytometryImmunotherapyMutation-independent neoantigen

Identifiers

PMID42400798

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.