ReviewProbiotics and antimicrobial proteins2026
Paradigm Shift of Microbiota-gut-brain Axis During Aging: Potential Role of Probiotics to Improve Cognitive Decline.
Review in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Population aging is a global demographic inevitability, driven by advancements in healthcare, increased life expectancy, and declining fertility rates. Growing evidence implicates gut microbiota dysbiosis in the pathogenesis of cognitive impairments and neurodegenerative disorders commonly associated with aging, primarily through disruptions in immune, metabolic, and neuroendocrine signaling along the gut-brain axis. This review synthesizes current literature on the therapeutic potential of probiotic bacteria, such as Lactobacillus and Bifidobacterium, to enhance glial function, maintain blood-brain barrier integrity, and neurocognitive performance in older adults. However, probiotic efficacy is highly strain-specific and context-dependent, necessitating individualized evaluation of each microbial strain's therapeutic profile. Future research should prioritize precision microbiome-based strategies to elucidate mechanisms of action, optimal strain combinations, and their effectiveness across varying degrees of cognitive decline in the aging population. Furthermore, diet, physical activity, and microbial exposures represent essential, non-pharmacological tools for maintaining microbiota eubiosis and supporting neurocognitive health in aging populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.