ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2026
Agreement between the EQ-5D-5L anxiety/depression dimension and GAD-7/PHQ-9 for psychological distress assessment in patients with hematologic malignancies.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- PIWIL4: from biological characteristics to disease pathogenesis and clinical applications.Frontiers in oncology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundPatients with hematologic malignancies (HMs) often experience psychological distress, significantly impairing health-related quality of life (HRQoL) and deteriorating clinical prognosis. Although the widely used instrument EuroQol 5-Dimension 5-Level (EQ-5D-5L) has been validated in the general population for accurately identifying the psychological symptoms, its performance in HM patients remains unclear. We aimed to investigate whether the EQ-5D-5L questionnaire anxiety/depression (A/D) dimension, when already collected for HRQoL assessment, correlates with anxiety and depression symptoms and may potentially flag patients who may warrant further psychiatric evaluation.
methodsEnrolled HM patients were invited to complete the EQ-5D-5L questionnaire. The anxiety/depression symptoms were additionally assessed using the symptom-specific tools Generalized Anxiety Disorder 7-item scale (GAD-7) and Patient Health Questionnaire-9 (PHQ-9). Spearman correlation analysis was performed to examine the correlation between the EQ-5D-5L A/D dimension and GAD-7/PHQ-9. The sensitivity and specificity of the A/D dimension were evaluated using GAD-7/PHQ-9 as a comparative measure. The associations between patient characteristics and responses on the A/D dimension were explored.
resultsThe A/D dimension exhibited moderate-to-strong correlations with GAD-7 grade (r = 0.607, P < 0.001), PHQ-9 grade (r = 0.579, P < 0.001), and combined GAD-7/PHQ-9 grade (r = 0.603, P < 0.001). For identifying the presence of anxiety/depression, the A/D dimension showed high specificity (94.3-98.6%) but relatively low sensitivity (47.2-60.0%). A subset of patients classified as having anxiety or depression according to the GAD-7/PHQ-9 reported no emotional problems on the A/D dimension. Further analysis revealed that patients with higher education level tended to report lower symptom severity on the A/D dimension.
conclusionsThe EQ-5D-5L A/D dimension showed moderate-to-strong correlation with GAD-7 and PHQ-9 among HM patients. Based on its limited sensitivity but high specificity, it may serve as a supplementary indicator within routine HRQoL assessments rather than a standalone screening tool. Due to the relatively small sample size and exploratory design of our study, further multicenter investigations with larger sample sizes are needed to validate our findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.